<i>C</i>. <i>sinensis</i> activated TLR2 signal pathway to aggravate biliary fibrosis through promoting IL-6 production.
- Yuru Wang (846969)
- Xu Zhang (49484)
- Xiaocen Wang (4055518)
- Nan Zhang (46264)
- Yanhui Yu (7323035)
- Pengtao Gong (4055521)
- Xichen Zhang (306024)
- Yeting Ma (14498201)
- Xin Li (51274)
- Jianhua Li (36075)
Publication date
January 2023
DOI Publisher
Public Library of Science (PLoS)Abstract
C. sinensis triggered AKT and p38 signal pathways dependent on TLR2 of BECs to promote the production of IL-6, which subsequently activated TGF-β1-Smad2/Smad3 pathways, myofibroblasts and up-regulated the expression of ECMs, finally resulting in biliary fibrosis in mice. In the figure, ‘↑’indicates positive regulation.</p
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