Abstract Understanding the interplay between nanoparticles (NPs) and cells is essential to designing more efficient nanomedicines. Previous research has shown the role of the cell cycle having impact on the efficiency of cellular uptake and accumulation of NPs. However, there is a limited investigation into the biological fate of NPs in cells that are permanently withdrawn from the cell cycle. Here we utilize senescent WI-38 fibroblasts, which do not divide and provide a definitive model for tracking the biological fate of silica nanoparticles (SiNPs) independent of cell cycle. We use several methods to measure the cellular uptake kinetics and intracellular retention of SiNPs, including confocal laser scanning microscopy (CLSM), flow cytome...
The toxicology of nanomaterials is a blooming field of study, yet it is difficult to keep pace with ...
Given the increasing variety of manufactured nanomaterials, suitable, robust, standardized in vitro ...
Silica-based luminescent nanoparticles (SiNPs) show promising prospects in nanomedicine in light of ...
In the fields of biology and medicine, nanoproducts such as nanoparticles (NPs) are specifically int...
Nanomedicine is gaining ground worldwide in therapy and diagnostics. Novel nanoscopic imaging probes...
International audienceThe long-term fate of fluorescent non-porous FITC-SiO2 nanoparticles of variou...
Introduction: Since most biologically active macromolecules are natural nanostructures, operating in...
The progressive accumulation of senescent cells in tissues in response to damage importantly contrib...
We report here in vitro evaluation of cellular nanoparticle uptake, cytotoxic effect and autophagy a...
International audienceBACKGROUND: The uptake of nanoparticles (NPs) by cells remains to be better ch...
none13noThe quantitative uptake of Silica nanoparticles (SiNPs), although representing an essential ...
Particle_in_Cell-3D is a powerful method to quantify the cellular uptake of nanoparticles. It combin...
Cellular uptake of nanoparticles for stem cell labeling/ tracking is considered as the most promisin...
[[abstract]]Cellular uptake of nanoparticles for stem cell labeling/tracking is considered as the mo...
A spatio-temporal mapping of the uptake of silica (SiO2) nanoparticles of different sizes by lung ep...
The toxicology of nanomaterials is a blooming field of study, yet it is difficult to keep pace with ...
Given the increasing variety of manufactured nanomaterials, suitable, robust, standardized in vitro ...
Silica-based luminescent nanoparticles (SiNPs) show promising prospects in nanomedicine in light of ...
In the fields of biology and medicine, nanoproducts such as nanoparticles (NPs) are specifically int...
Nanomedicine is gaining ground worldwide in therapy and diagnostics. Novel nanoscopic imaging probes...
International audienceThe long-term fate of fluorescent non-porous FITC-SiO2 nanoparticles of variou...
Introduction: Since most biologically active macromolecules are natural nanostructures, operating in...
The progressive accumulation of senescent cells in tissues in response to damage importantly contrib...
We report here in vitro evaluation of cellular nanoparticle uptake, cytotoxic effect and autophagy a...
International audienceBACKGROUND: The uptake of nanoparticles (NPs) by cells remains to be better ch...
none13noThe quantitative uptake of Silica nanoparticles (SiNPs), although representing an essential ...
Particle_in_Cell-3D is a powerful method to quantify the cellular uptake of nanoparticles. It combin...
Cellular uptake of nanoparticles for stem cell labeling/ tracking is considered as the most promisin...
[[abstract]]Cellular uptake of nanoparticles for stem cell labeling/tracking is considered as the mo...
A spatio-temporal mapping of the uptake of silica (SiO2) nanoparticles of different sizes by lung ep...
The toxicology of nanomaterials is a blooming field of study, yet it is difficult to keep pace with ...
Given the increasing variety of manufactured nanomaterials, suitable, robust, standardized in vitro ...
Silica-based luminescent nanoparticles (SiNPs) show promising prospects in nanomedicine in light of ...