Abstract Background Accurate regulation of DNA methylation is necessary for normal cells to differentiate, develop and function. TET2 catalyzes stepwise DNA demethylation in hematopoietic cells. Mutations in the TET2 gene predispose to hematological malignancies by causing DNA methylation overload and aberrant epigenomic landscape. Studies on mice and cell lines show that the function of TET2 is boosted by vitamin C. Thus, by strengthening the demethylation activity of TET2, vitamin C could play a role in the prevention of hematological malignancies in individuals with TET2 dysfunction. We recently identified a family with lymphoma predisposition where a heterozygous truncating germline mutation in TET2 segregated with nodular lymphocyte-pr...
Acute myeloid leukaemia (AML) is a deadly disease characterised by the abnormal proliferation of imm...
The α-KG-dependent tumor suppressor ten-eleven translocation methyl-cytosine dioxygenase 2 (TET2) is...
Abstract Clonal hematopoiesis driven by somatic heterozygous TET2 loss is linked to malignant degen...
Background Accurate regulation of DNA methylation is necessary for normal cells to differentiate, de...
DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and t...
DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and t...
Abstract Background Histone methylation patterns regulate gene expression and are highly dynamic dur...
The genomes of myeloid malignancies are characterized by epigenomic abnormalities. Heterozygous, ina...
Histone methylation patterns regulate gene expression and are highly dynamic during development. The...
Dendritic cells (DCs), the most potent antigen-presenting cells, are necessary for effective activat...
Neomorphic mutations in isocitrate dehydrogenase 1/2 (IDH1/2) and inactivating mutations in ten elev...
DNA methylation is an abundant and stable epigenetic modification that allows inheritance of informa...
DNA demethylation is promoted by TET enzymes, a family of three proteins -TET1, TET2 and TET3- which...
Background Patients with haematological malignancies are often vitamin C deficient, and vitamin C is...
Maintenance of balances of DNA methylation and demethylation plays fundamental roles in many biologi...
Acute myeloid leukaemia (AML) is a deadly disease characterised by the abnormal proliferation of imm...
The α-KG-dependent tumor suppressor ten-eleven translocation methyl-cytosine dioxygenase 2 (TET2) is...
Abstract Clonal hematopoiesis driven by somatic heterozygous TET2 loss is linked to malignant degen...
Background Accurate regulation of DNA methylation is necessary for normal cells to differentiate, de...
DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and t...
DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and t...
Abstract Background Histone methylation patterns regulate gene expression and are highly dynamic dur...
The genomes of myeloid malignancies are characterized by epigenomic abnormalities. Heterozygous, ina...
Histone methylation patterns regulate gene expression and are highly dynamic during development. The...
Dendritic cells (DCs), the most potent antigen-presenting cells, are necessary for effective activat...
Neomorphic mutations in isocitrate dehydrogenase 1/2 (IDH1/2) and inactivating mutations in ten elev...
DNA methylation is an abundant and stable epigenetic modification that allows inheritance of informa...
DNA demethylation is promoted by TET enzymes, a family of three proteins -TET1, TET2 and TET3- which...
Background Patients with haematological malignancies are often vitamin C deficient, and vitamin C is...
Maintenance of balances of DNA methylation and demethylation plays fundamental roles in many biologi...
Acute myeloid leukaemia (AML) is a deadly disease characterised by the abnormal proliferation of imm...
The α-KG-dependent tumor suppressor ten-eleven translocation methyl-cytosine dioxygenase 2 (TET2) is...
Abstract Clonal hematopoiesis driven by somatic heterozygous TET2 loss is linked to malignant degen...