Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer
- Michael J. P. Crowley
- Bhavneet Bhinder
- Geoffrey J. Markowitz
- Mitchell Martin
- Akanksha Verma
- Tito A. Sandoval
- Chang-Suk Chae
- Shira Yomtoubian
- Yang Hu
- Sahil Chopra
- Diamile A. Tavarez
- Paolo Giovanelli
- Dingcheng Gao
- Timothy E. McGraw
- Nasser K. Altorki
- Olivier Elemento
- Juan R. Cubillos-Ruiz
- Vivek Mittal
Publication date
January 2023
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
The IRE1α-XBP1 arm of the unfolded protein response (UPR) has been associated with immunosuppression and cancer progression. Here the authors show that IRE1α-XBP1 activation is associated with poor overall survival in patients with non-small cell lung cancer and that IRE1α loss in cancer cells promotes anti-tumor immune responses in lung cancer preclinical models
Add to ORKG