IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and has become an attractive target for treating lipid metabolism disorders in recent years. Thus, in this study, we discovered CS271011, a novel THR-β agonist, and assessed the safety and efficiency of CS271011 compared to MGL-3196 in vitro and in vivo. MethodsWe conducted luciferase reporter gene assays to assess the activation of THR-β and α in vitro. C57BL/6J mice were fed a high-fat diet for 12 weeks, CS271011 was administered by gavage at the dose of 1 mg/kg and 3 mg/kg, and MGL-3196 was administered at the dose of 3 mg/kg for 10 weeks. Body weight, food intake, serum and hepatic parameters, histological analysis, pharmacokinetic studies, RNA...
Background and Purpose: Activation of hepatic thyroid hormone receptor β (THR-β) is associated with ...
Thyroid hormones (THs) elicit significant effects on numerous physiological processes, such as growt...
Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease in the United St...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
: Activation of thyroid hormone receptor β (THRβ) has shown beneficial effects on metabolic alterati...
Activation of thyroid hormone receptor β(THRβ) has shown beneficial effects on metabolic alterations...
Background and Purpose: Activation of hepatic thyroid hormone receptor β (THR-β) is associated with ...
Thyroid hormones (THs) elicit significant effects on numerous physiological processes, such as growt...
Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease in the United St...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
IntroductionThyroid hormone receptor β (THR-β) plays a critical role in metabolism regulation and ha...
: Activation of thyroid hormone receptor β (THRβ) has shown beneficial effects on metabolic alterati...
Activation of thyroid hormone receptor β(THRβ) has shown beneficial effects on metabolic alterations...
Background and Purpose: Activation of hepatic thyroid hormone receptor β (THR-β) is associated with ...
Thyroid hormones (THs) elicit significant effects on numerous physiological processes, such as growt...
Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease in the United St...