Cloud computing has emerged as a successful paradigm allowing individuals and companies to store and process large amounts of data without a need to purchase and maintain their own networks and computer systems. In healthcare for example, different initiatives aim at sharing medical images and Personal Health Records (PHR) in between health professionals or hospitals with the help of the cloud. In such an environment, data security (confidentiality, integrity and traceability) is a major issue. In this context that these thesis works, it concerns in particular the securing of Content Based Image Retrieval (CBIR) techniques and machine learning (ML) which are at the heart of diagnostic decision support systems. These techniques make it possi...