Prognostic factors for the sequelae and severity of Guillain‐Barré syndrome in children

International audienceIntroduction: Guillain-Barré syndrome (GBS) is an inflammatory polyradiculoneuritis.Our aim in this study was to describe the clinical characteristics and the long-termsequelae of GBS in a French pediatric population.Methods: In this multicenter, retrospective study we evaluated clinical signs, radio-logical examinations, laboratory tests, treatments, and outcomes.Results: One hundred ten children were included in this investigation. These childrenpresented with walking difficulties, muscle weakness, and cranial nerve impairment.Electrodiagnostic testing revealed 70% with acute inflammatory demyelinating poly-radiculoneuropathy (AIDP) and 16% with acute motor axonal neuropathy (AMAN).One hundred children received immunoglobulins. At follow-up, 77% were cured,whereas 9% had sequelae, associated with an axonal form (P < .01) and a short inter-val between symptom onset and hospitalization (P < .01). The need for intubationwas correlated with peripheral facial paralysis (P < .01) and dysautonomia (P < .01).Discussion: Although AIDP and AMAN present in a similar way, the axonal form isassociated with a worse outcome