Catalytic Enantioselective Synthesis of 2,3′-Bis(indolyl)methanes Bearing All-Carbon Quaternary Stereocenters via 2‑Indole Imine Methides

An organocatalytic enantioselective formal hydroarylation of 2-vinyl indoles for the preparation of enantioenriched 2,3′-bis(indolyl)methanes bearing an all-carbon quaternary stereocenter is described. This reaction features mild conditions, low catalyst loading, excellent efficiency and enantioselectivity. The obtained products showed promising anticancer activity