Anomalies in past neutrino measurements have led to the discovery that these particles have non-zero mass and oscillate between their three flavours when they propagate. In the 2010s, similar anomalies observed in the antineutrino spectra emitted by nuclear reactors have triggered the hypothesis of the existence of a supplementary neutrino state that would be sterile, that is, not interacting by means of the weak interaction1. The STEREO experiment was designed to investigate this conjecture, which would potentially extend the standard model of particle physics. Here we present an analysis of the full set of data generated by STEREO, confirming observed anomalies while rejecting the hypothesis of a light sterile neutrino. Installed at the I...