The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data and RNA sequencing from a common set of 1220 cancer cases, we report hundreds of genes for which the presence within 100 kb of an SV breakpoint associates with altered expression. For the majority of these genes, expression increases rather than decreases with corresponding breakpoint events. Up-regulated cancer-associated genes impacted by this phenomenon include TERT, MDM2, CDK4, ERBB2, CD274, PDCD1LG2, and IGF2. TERT-associated breakpoints involve ~3% of cases, most frequently in liver biliary, melanoma, sarcom...
Imbalanced expression of somatic alleles in cancer can suggest functional and selective features, an...
Extensive prior research focused on somatic copy-number alterations (SCNAs) affecting cancer genes, ...
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled syst...
The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Her...
The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Her...
A systematic cataloging of genes affected by genomic rearrangement, using multiple patient cohorts a...
Both proteome and transcriptome data can help assess the relevance of non-coding somatic alterations...
Summary: The global impact of somatic structural variants (SVs) on gene regulation in advanced tumor...
Chromatin is folded into successive layers to organize linear DNA. Genes within the same topological...
Chromatin is folded into successive layers to organize linear DNA. Genes within the same topological...
Background: Genomic rearrangements exert a heavy influence on the molecular landscape of cancer. New...
Abstract Background Recent large-scale cancer sequencing studies have discovered many novel cancer d...
Cancer is characterised by somatic genetic variation, but the effect of the majority of non-coding s...
Comprehensive identification of somatic structural variations (SVs) and understanding their mutation...
Imbalanced expression of somatic alleles in cancer can suggest functional and selective features, an...
Extensive prior research focused on somatic copy-number alterations (SCNAs) affecting cancer genes, ...
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled syst...
The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Her...
The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Her...
A systematic cataloging of genes affected by genomic rearrangement, using multiple patient cohorts a...
Both proteome and transcriptome data can help assess the relevance of non-coding somatic alterations...
Summary: The global impact of somatic structural variants (SVs) on gene regulation in advanced tumor...
Chromatin is folded into successive layers to organize linear DNA. Genes within the same topological...
Chromatin is folded into successive layers to organize linear DNA. Genes within the same topological...
Background: Genomic rearrangements exert a heavy influence on the molecular landscape of cancer. New...
Abstract Background Recent large-scale cancer sequencing studies have discovered many novel cancer d...
Cancer is characterised by somatic genetic variation, but the effect of the majority of non-coding s...
Comprehensive identification of somatic structural variations (SVs) and understanding their mutation...
Imbalanced expression of somatic alleles in cancer can suggest functional and selective features, an...
Extensive prior research focused on somatic copy-number alterations (SCNAs) affecting cancer genes, ...
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled syst...