β-hydroxybutyrate (β-OHB) is an essential metabolic energy source during fasting and functions as a chromatin regulator by lysine β-hydroxybutyrylation (Kbhb) modification of the core histones H3 and H4. We report that Kbhb on histone H3 (H3K9bhb) is enriched at proximal promoters of critical gene subsets associated with lipolytic and ketogenic metabolic pathways in small intestine (SI) crypts during fasting. Similar Kbhb enrichment is observed in Lgr5+ stem cell-enriched epithelial spheroids treated with β-OHB in vitro. Combinatorial chromatin state analysis reveals that H3K9bhb is associated with active chromatin states and that fasting enriches for an H3K9bhb-H3K27ac signature at active metabolic gene promoters and distal enhancer elemen...
Autophagy, a self-degradative physiological process, is critical for homeostasis maintenance and ene...
Ketone bodies are bioactive metabolites that function as energy substrates, signaling molecules, and...
IκBs exert principal functions as cytoplasmic inhibitors of NF-kB transcription factors. Additional ...
Little is known about how metabolites couple tissuespecific stem cell function with physiology. Here...
Various forms of fasting and ketogenic diet have shown promise in (pre-)clinical studies to normaliz...
Various forms of fasting and ketogenic diet have shown promise in (pre-)clinical studies to normaliz...
Background - Fasting has dramatic effects on small intestinal transport function. However, little is...
Abstract Background The gut is a major energy consumer, but a comprehensive overview of the adaptive...
International audienceCirculating pancreatic glucagon is increased during fasting and maintains gluc...
Objective: We previously reported that β-oxidation enzymes are present in the nucleus in close proxi...
Ketone bodies are short-chain fatty acids produced in the liver during periods of limited glucose av...
International audienceThe recently discovered histone post-translational modification crotonylation ...
Ketosis is a metabolic condition that occurs during heat stress, prolonged exercise, fasting, and in...
Aims: Insufficient insulin release by β-cells is the primary etiology in type 2 diabetes and coinci...
The intestinal microbiota have a vital role in aiding digestion by metabolising dietary fibres. In t...
Autophagy, a self-degradative physiological process, is critical for homeostasis maintenance and ene...
Ketone bodies are bioactive metabolites that function as energy substrates, signaling molecules, and...
IκBs exert principal functions as cytoplasmic inhibitors of NF-kB transcription factors. Additional ...
Little is known about how metabolites couple tissuespecific stem cell function with physiology. Here...
Various forms of fasting and ketogenic diet have shown promise in (pre-)clinical studies to normaliz...
Various forms of fasting and ketogenic diet have shown promise in (pre-)clinical studies to normaliz...
Background - Fasting has dramatic effects on small intestinal transport function. However, little is...
Abstract Background The gut is a major energy consumer, but a comprehensive overview of the adaptive...
International audienceCirculating pancreatic glucagon is increased during fasting and maintains gluc...
Objective: We previously reported that β-oxidation enzymes are present in the nucleus in close proxi...
Ketone bodies are short-chain fatty acids produced in the liver during periods of limited glucose av...
International audienceThe recently discovered histone post-translational modification crotonylation ...
Ketosis is a metabolic condition that occurs during heat stress, prolonged exercise, fasting, and in...
Aims: Insufficient insulin release by β-cells is the primary etiology in type 2 diabetes and coinci...
The intestinal microbiota have a vital role in aiding digestion by metabolising dietary fibres. In t...
Autophagy, a self-degradative physiological process, is critical for homeostasis maintenance and ene...
Ketone bodies are bioactive metabolites that function as energy substrates, signaling molecules, and...
IκBs exert principal functions as cytoplasmic inhibitors of NF-kB transcription factors. Additional ...