Assess the overall postoperative morbidity among patients with brain tumors by using preoperative functional magnetic resonance imaging: A systematic review and meta-analysis

Background and aim: the aim of present study was Assessing the Overall Postoperative morbidity among patients with brain tumors by using preoperative functional Magnetic Resonance Imaging. Method: Databases of PubMed, Scopus, Web of Science, EBSCO, ISI Web of knowledge and Embase were searched for systematic literature between 2012 to July 2022.  95% confidence interval for odds ratio with fixed effect model and Mantel–Haenszel method and were calculated. To deal with potential heterogeneity, random effects were used and I2 showed heterogeneity. Meta-analysis was performed using Stata/MP v.17 software. Result: In the initial review, duplicate studies were eliminated and abstracts of 178 studies were reviewed, the full text of 32 studies was reviewed by two authors, finally, six studies were selected. Odds ratio of Unfavorable outcomes between functional MRI and control group was 0.46 (OR, 95% CI 0.15, 0.76; p<0.001). Odds ratio of Gross total resection between functional MRI and control group was 0.20 (OR, 95% CI -0.20, 0.59; p=0.34). Conclusion: According to the findings of the present study, the use of functional MRI before brain tumor removal is associated with a reduction in the risk of delayed or permanent neurological deficits after surgery with a two-month follow-up period