Laser speckle contrast imaging for monitoring of acute pancreatitis at ischemia-reperfusion injury of the pancreas in rats

The in°uence of ischemia–reperfusion (I/R) action on pancreatic blood °ow (PBF) and the development of acute pancreatitis (AP) in laboratory rats is evaluated in vivo by using the laser speckle contrast imaging (LSCI). Additionally, the optical properties in norm and under condition of AP in rats were assessed using a modi¯ed integrating sphere spectrometer and inverse Monte Carlo (IMC) software. The results of the experimental study of microcirculation of the pancreas in 82 rats in the ischemic model are presented. The data obtained con¯rm the fact that local ischemia and changes in the blood °ow velocity of the main vessels cause and provoke acute pancreatitis