(A) Multiple sequence alignment of S. cerevisiae Hel2, H. sapiens ZNF598, and C. elegans ZNF-598 RING finger domains. Conserved residues (gray) and C89 (orange) are highlighted. Conservation below alignment is as follows: asterisks indicate identity, colons indicate amino acids with strongly similar properties, periods indicate amino acids with weakly similar properties. (B) Mean RFUs (relative fluorescence units) of indicated strains (n≥15 animals/strain) in the unc-54(rareArg) background. One standard deviation shown as error bars. p values from Welch’s t-test. (C) Western blot of indicated strains to monitor RPS-20 and RPS-10 expression. Dilutions of wild type tagged proteins were loaded as indicated, with two-fold more and two-fold less...
For over 30 years, researchers have taken advantage of genetic balancers and forward genetic screens...
<p>(A) Amino acid alignment of the human and <i>C. elegans</i> Folliculin sequences (accession numbe...
The removal of introns from eukaryotic RNA transcripts requires the activities of five multi-compone...
(A) Pairwise sequence alignment of H. sapiens eS10 and C. elegans RPS-10. K125 is highlighted in gre...
Background: The eukaryotic ubiquitin-conjugation system sets the turnover rate of m...
<p>Comparison of the deduced amino acid sequences. Dashes indicate the arrangement of the sequences ...
Ubiquitin-mediated proteolysis is an ATP-dependent pathway that targets proteins for degradation in ...
<p>(<i>A</i>) Amino acid sequence alignment of the C-terminal ends of the CELF family proteins and t...
AbstractIn a yeast two-hybrid screen, RING finger protein 1 (RFP-1) and UBR1 were identified as pote...
Abstract Background Ribosomal protein genes (RPGs) are essential, tightly regulated, and highly expr...
<div><p>(A) Schematic illustration of the transcripts and proteins of <i>zfp-1</i> (<a href="http://...
The removal of introns from eukaryotic RNA transcripts requires the activities of five multi-compone...
Background: The C. elegans genome has been extensively annotated by the WormBase consortium that use...
<p>(A) Alignment of <i>C. elegans</i> BUB-1 (<a href="http://www.wormbase.org/db/seq/protein?name=WP...
<div><p>(A) Multiple sequence alignment of C. elegans H3, H3.3, and H3.3-like proteins. The red box ...
For over 30 years, researchers have taken advantage of genetic balancers and forward genetic screens...
<p>(A) Amino acid alignment of the human and <i>C. elegans</i> Folliculin sequences (accession numbe...
The removal of introns from eukaryotic RNA transcripts requires the activities of five multi-compone...
(A) Pairwise sequence alignment of H. sapiens eS10 and C. elegans RPS-10. K125 is highlighted in gre...
Background: The eukaryotic ubiquitin-conjugation system sets the turnover rate of m...
<p>Comparison of the deduced amino acid sequences. Dashes indicate the arrangement of the sequences ...
Ubiquitin-mediated proteolysis is an ATP-dependent pathway that targets proteins for degradation in ...
<p>(<i>A</i>) Amino acid sequence alignment of the C-terminal ends of the CELF family proteins and t...
AbstractIn a yeast two-hybrid screen, RING finger protein 1 (RFP-1) and UBR1 were identified as pote...
Abstract Background Ribosomal protein genes (RPGs) are essential, tightly regulated, and highly expr...
<div><p>(A) Schematic illustration of the transcripts and proteins of <i>zfp-1</i> (<a href="http://...
The removal of introns from eukaryotic RNA transcripts requires the activities of five multi-compone...
Background: The C. elegans genome has been extensively annotated by the WormBase consortium that use...
<p>(A) Alignment of <i>C. elegans</i> BUB-1 (<a href="http://www.wormbase.org/db/seq/protein?name=WP...
<div><p>(A) Multiple sequence alignment of C. elegans H3, H3.3, and H3.3-like proteins. The red box ...
For over 30 years, researchers have taken advantage of genetic balancers and forward genetic screens...
<p>(A) Amino acid alignment of the human and <i>C. elegans</i> Folliculin sequences (accession numbe...
The removal of introns from eukaryotic RNA transcripts requires the activities of five multi-compone...