Application of New Nanostructured Materials in Furcation Defects Therapy

The potential use of calcium phosphate cements in endodontic therapy is an active area of research. Hydroxyapatite is one of the most commonly used calcium phosphate materials in medicine and dentistry. Biocompatibility of hydroxyapatite is closely related to its chemical composition, similar to dental and bony tissues. Recent studies have focused on new and modified formulations of calcium-phosphate-based biomaterials with improved mechanical and maintained favorable biological properties. Recently, two non-commercial new nanomaterials based on calcium silicates and hydroxyapatite have been synthesized. One is a calcium silicate system of tricalcium and dicalcium silicates (CS), and the other one is a mixture of the calcium silicate system and hydroxyapatite (HA-CS). Both CS and HA-CS are nanostructural materials. Particle size affects cement hydration and consequently setting time and final quality of the cement. Fast setting is a clear clinical advantage while cement composition and internal nanostructure are expected to provide biological behavior in vital tissues. The problem with furcation perforation repair is still not agreed upon as no currently available materials meet all the requirements of an ideal repair material as defined in the literature. Therefore, this study aimed to compare the tissue reaction of two new repair materials for furcation perforations