Implantogenomic: Conceptualizing Osseointegration Toward Personalized Dental Implant Therapy

The spectrum of patients’ needs for dental implant treatment ranges between healthy individuals to those with complex diseases and compromised jaw bones. The aim of this review chapter is to introduce the application of personalized dental medicine to dental implant field as a therapeutic strategy that is best suited to individualized patient’s genetic makeup “Implantogenomics” to enhance their longevity and clinical outcomes. The ultimate goal of personalized medicine and dentistry is tailoring targeted treatment to the patient’s individual genetic makeup and having predictive outcomes. This approach will transfer the traditionally known “one size fits all” to an actionable model, tailoring therapy to individuals in a homogenous stratified group. In this review chapter, in analogy to pharmacogenomics, personalized dental implant and its implantogenomics concept have been proposed as a novel application of personalized dentistry. It is conceivable that the actionable model that integrates genomics and materiomics will accelerate the production of personalized implantable biomaterials and biomedical devices. Moreover, the convergence of multi-disciplines including biological sciences, material sciences, and computational tools may underpin the application of personalized dental implant therapy in the future. This approach will unleash the potential of advancing technologies to tailor dental implants targeting different subpopulations. Despite this optimistic goal, challengeable remains ahead of us where the conduction of well-directed scientific and clinical research is needed