This article engages the Nietzschean problem of nihilism from a “cross-cultural”, comparative vantage-point. In Nietzsche’s diagnosis of the “sickness” of nihilism, the measure of that illness is taken with reference to a particular conception of health – rooted in Nietzsche’s relational ontology of the will to power. Here, instead, I wish to take the possible nature and entailments of relationality as an open question to be pursued in conversation with Indigenous American and especially Amazonian Kichwa thinking. Doing so, I argue, allows for a distinctive kind of gloss on how we might think about what is impoverishing in nihilism, and also opens distinctive horizons for exploring what it might mean to live otherwise, to pursue health. To ...