Synergistic Cloud Point Microextraction Prior to Spectrophotometric Determination of Curcumin in Food Samples

© 2022 Taylor & Francis Group, LLC.Synergistic cloud point microextraction (SCPME) significantly simplifies and accelerates traditional cloud point extraction (CPE). The use of medium- to long-chain alcohols such as pentan-1-ol reduces the cloud point temperature of the surfactant below room temperature without salt addition or heating, which minimizes the extraction time. In this work, SCPME with Triton X-405, as a nonionic surfactant, and pentan-1-ol, as a synergic agent, were applied for the extraction of curcumin prior to its determination with UV/Vis spectrophotometry. The optimum SCPME conditions were achieved with 500 µL of Triton X-405 and 600 µL of pentan-1-ol in 10.0 mL of the sample solution with an analysis time of 8.5 min. Curcumin was monitored at 430.0 nm. The limits of detection ranged from 0.012 to 0.027 µg mL−1 and the coefficients of determination (R 2) of the calibration graphs were higher than 0.9974. The proposed SCPME-UV/Vis method was applied for the extraction and determination of curcumin in food samples. The relative recoveries ranged from 90.6 to 105.4% with relative standard deviations below 7.5%