In this paper, the isotropic compliance property is examined in the Special Euclidean Group SE(3). The relation between the wrench and the resulting twist is examined, considering an end-effector of 6 D.O.F. serial manipulators. Two properties are introduced. The first one, called local isotropic compliance, is verified if the force vector is parallel to the tip point displacement vector, and, at the same time, if the torque vector is parallel to the change of orientation vector. The second one, called screw isotropic compliance, is verified if the wrench screw axis is parallel to the twist screw axis. In the latter case, the wrench and twist screw axes are generally not coincident in the Cartesian space. If they are, the contact point coul...