This paper proposes a method for the automatic and simultaneous identification of the body-in-white assembly cell design and motion plan. The method solution is based on an iterative algorithm that looks for a global optimum by iteratively identifying the optimum of three sub-problems. These sub-problems concern system layout design and motion planning for single and multi-robot systems, while collision detection is addressed. The sub-problems are handled through ad-hoc developed Mixed Integer Programming (MIP) models. The proposed solution overcomes the limitations of the current design and motion plan approaches. In fact, the design of body-in-white assembly cell and the robot motion planning are two time-expensive and interconnected acti...