This article belongs to the Special Issue Neuroepigenetic: From Bench to Bedside.The peripheral nervous system (PNS) has a remarkable regenerative capacity in comparison to the central nervous system (CNS), a phenomenon that is impaired during ageing. The ability of PNS axons to regenerate after injury is due to Schwann cells (SC) being reprogrammed into a repair phenotype called Repair Schwann cells. These repair SCs are crucial for supporting axonal growth after injury, myelin degradation in a process known as myelinophagy, neurotropic factor secretion, and axonal growth guidance through the formation of Büngner bands. After regeneration, repair SCs can remyelinate newly regenerated axons and support nonmyelinated axons. Increasing eviden...
Peripheral neuropathies (PN) represent a significant health burden, due to chronic and de...
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regener...
The work within examined different aspects of the Schwann cell (SC) development and injury response...
The peripheral nervous system (PNS) has a remarkable regenerative capacity in comparison to the cent...
The peripheral nervous system (PNS) regenerates after injury. However, regeneration is often compro...
The peripheral nervous system (PNS) regenerates after injury. However, regeneration is often comprom...
Abstract Background Epigenetic regulation by histone deacetylases (HDACs) in Schwann cells (SCs) aft...
The molecular mechanisms discriminating between regenerative failure and success remain elusive. Whi...
The molecular mechanisms discriminating between regenerative failure and success remain elusive. Whi...
Myelinated axons are a beautiful example of symbiotic interactions between two cell types: Myelinati...
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissue...
Summary: The formation of myelinating Schwann cells (mSCs) involves the remarkable biogenic process,...
INTRODUCTION: Peripheral neuropathies are a heterogeneous group of diseases that are characterized b...
In the normal peripheral nervous system, Schwann cells (SCs) are present in two different states of ...
Outcomes for patients following major peripheral nerve injury are extremely poor. Despite advanced m...
Peripheral neuropathies (PN) represent a significant health burden, due to chronic and de...
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regener...
The work within examined different aspects of the Schwann cell (SC) development and injury response...
The peripheral nervous system (PNS) has a remarkable regenerative capacity in comparison to the cent...
The peripheral nervous system (PNS) regenerates after injury. However, regeneration is often compro...
The peripheral nervous system (PNS) regenerates after injury. However, regeneration is often comprom...
Abstract Background Epigenetic regulation by histone deacetylases (HDACs) in Schwann cells (SCs) aft...
The molecular mechanisms discriminating between regenerative failure and success remain elusive. Whi...
The molecular mechanisms discriminating between regenerative failure and success remain elusive. Whi...
Myelinated axons are a beautiful example of symbiotic interactions between two cell types: Myelinati...
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissue...
Summary: The formation of myelinating Schwann cells (mSCs) involves the remarkable biogenic process,...
INTRODUCTION: Peripheral neuropathies are a heterogeneous group of diseases that are characterized b...
In the normal peripheral nervous system, Schwann cells (SCs) are present in two different states of ...
Outcomes for patients following major peripheral nerve injury are extremely poor. Despite advanced m...
Peripheral neuropathies (PN) represent a significant health burden, due to chronic and de...
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regener...
The work within examined different aspects of the Schwann cell (SC) development and injury response...