Immune Imprinting and Protection against Repeat Reinfection with SARS-CoV-2
- Chemaitelly, Hiam
- Ayoub, Houssein H.
- Tang, Patrick
- Hasan, Mohammad R.
- Coyle, Peter
- Yassine, Hadi M.
- Al-Khatib, Hebah A.
- Smatti, Maria K.
- Al-Kanaani, Zaina
- Al-Kuwari, Einas
- Jeremijenko, Andrew
- Kaleeckal, Anvar H.
- Latif, Ali N.
- Shaik, Riyazuddin M.
- Abdul-Rahim, Hanan F.
- Nasrallah, Gheyath K.
- Al-Kuwari, Mohamed G.
- Butt, Adeel A.
- Al-Romaihi, Hamad E.
- Al-Thani, Mohamed H.
- Al-Khal, Abdullatif
- Bertollini, Roberto
- Abu-Raddad, Laith J.
Publication date
November 2022
DOI Publisher
Massachusetts Medical Society Journal
New England Journal of MedicineAbstract
More than 2 years into the coronavirus disease 2019 (Covid-19) pandemic, the global population carries heterogeneous immune histories derived from various exposures to infection, viral variants, and vaccination.1 Evidence at the level of binding and neutralizing antibodies and B-cell and T-cell immunity suggests that a history of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can have a negative effect on subsequent protective immunity.1 In particular, the immune response to B.1.1.529 (omicron) subvariants could be compromised by differential immune imprinting in persons who have had a previous infection with the original virus or the B.1.1.7 (alpha) variant.
Add to ORKG