(A) Example of how the models fit to the data from the liver from one of the rats. (B-D) Correlations between the logarithm of the gadoxetate uptake rate, ki, estimated using (B) the Patlak and Whole-Body models, (C) the Perfusion model, with input from the spleen, and the Patlak model, (D) the Perfusion model, with input from the spleen, and the Whole-Body model.</p
<p>Data are expressed as the mean ± SEM. ALT, alanine aminotransferase; AST, aspartate aminotransfer...
<p><b>A</b>: Rats fed RD and treated by gavage daily for twenty-eight consecutive days with vehicle ...
The adipose tissue:blood partition coefficient is a key‐endpoint to predict the pharmacokinetics of ...
(A) Example of how well the models fitted to the data from the liver from a typical patient. (B-F) C...
(A) The extended Patlak model, now including the effects of the drug on the transport rates. (B) The...
a<p>All the parameters are defined in the <a href="http://www.plosone.org/article/info:doi/10.1371/j...
<p>(A) Score plot and (B) loading plot derived from PCA model classifying control rats (■) and model...
Dataset to accompany the manuscript "Use of In Vivo Imaging and Physiologically-Based Kinetic Modell...
<p>Pharmacokinetic parameter estimates for mice, rats, and dogs obtained by simultaneously fitting o...
The figure shows likelihood profiles of the gadoxetate uptake rate, ki, estimated using data from th...
The liver receives two blood supplies, portal and hepatic, yet most in situ studies use only portal ...
<p>Biochemical parameters for the physiologically based model for GL, GA and GAM in rat.</p
(A) Model. Gadoxetate, a gadolinium ion (Gd3+)-containing MRI-contrast agent, is taken up by hepatoc...
(A) The score plot of PLS-DA separated 9-month from 18-month (permutation test, P = 0.001). (B) Load...
<p>Mean (± SD) of the plasma concentration-time curves of <i>C2</i> in rats following (A) intravenou...
<p>Data are expressed as the mean ± SEM. ALT, alanine aminotransferase; AST, aspartate aminotransfer...
<p><b>A</b>: Rats fed RD and treated by gavage daily for twenty-eight consecutive days with vehicle ...
The adipose tissue:blood partition coefficient is a key‐endpoint to predict the pharmacokinetics of ...
(A) Example of how well the models fitted to the data from the liver from a typical patient. (B-F) C...
(A) The extended Patlak model, now including the effects of the drug on the transport rates. (B) The...
a<p>All the parameters are defined in the <a href="http://www.plosone.org/article/info:doi/10.1371/j...
<p>(A) Score plot and (B) loading plot derived from PCA model classifying control rats (■) and model...
Dataset to accompany the manuscript "Use of In Vivo Imaging and Physiologically-Based Kinetic Modell...
<p>Pharmacokinetic parameter estimates for mice, rats, and dogs obtained by simultaneously fitting o...
The figure shows likelihood profiles of the gadoxetate uptake rate, ki, estimated using data from th...
The liver receives two blood supplies, portal and hepatic, yet most in situ studies use only portal ...
<p>Biochemical parameters for the physiologically based model for GL, GA and GAM in rat.</p
(A) Model. Gadoxetate, a gadolinium ion (Gd3+)-containing MRI-contrast agent, is taken up by hepatoc...
(A) The score plot of PLS-DA separated 9-month from 18-month (permutation test, P = 0.001). (B) Load...
<p>Mean (± SD) of the plasma concentration-time curves of <i>C2</i> in rats following (A) intravenou...
<p>Data are expressed as the mean ± SEM. ALT, alanine aminotransferase; AST, aspartate aminotransfer...
<p><b>A</b>: Rats fed RD and treated by gavage daily for twenty-eight consecutive days with vehicle ...
The adipose tissue:blood partition coefficient is a key‐endpoint to predict the pharmacokinetics of ...