Dose-response of the drug in rats.

(A, D) show the estimated ki and kef grouped by drug dose. (B, E) show dose-response plots for ki and kef, respectively. The black curve is the dose response function and the gray lines shows the IC50 point. (C, F) show the variation of each parameter for each rat, i.e., how much the individual parameter values deviates from the value expected by the dose-response function.