The anti-neoplastic sphingolipid analog SH-BC-893 starves cancer cells to death by down-regulating cell surface nutrient transporters and blocking lysosomal trafficking events. These effects are mediated by the activation of protein phosphatase 2A (PP2A). To identify putative PP2A substrates, we used quantitative phosphoproteomics to profile the temporal changes in protein phosphorylation in FL5.12 cells following incubation with SH-BC-893 or the specific PP2A inhibitor LB-100. These analyses enabled the profiling of more than 15,000 phosphorylation sites, of which 958 sites on 644 proteins were dynamically regulated. We identified 114 putative PP2A substrates including several nutrient transporter proteins, GTPase regulators (e.g. Agap2, G...
Sphingosine kinase 1 (SK1) is an important regulator of cellular signaling that has been implicated ...
The phosphorylation and dephosphorylation of proteins by kinases and phosphatases constitute an esse...
Summary: Despite its low cellular abundance, phosphotyrosine (pTyr) regulates numerous cell signalin...
The anti-neoplastic sphingolipid analog SH-BC-893 starves cancer cells to death by down-regulating c...
Despite the advances in therapeutics targeting key players that drive cancer metabolism, clinical be...
Sphingolipids (SLs) are essential components of cell membranes and are broad-range bioactive signali...
Sphingolipids are found in all kingdoms of life. In mammals, sphingolipids regulate multiple cellula...
Sphingolipids (SLs) are essential components of cell membranes and are broad-range bioactive signali...
Sphingolipids are found in all kingdoms of life. In mammals, sphingolipids regulate multiple cellula...
[[abstract]]There are a large number of signalling pathways responsible for transmitting information...
Sphingolipid metabolites regulate cell fate by acting on specific cellular targets. We used affinity...
[[abstract]]There are a large number of signalling pathways responsible for transmitting information...
[[abstract]]There are a large number of signalling pathways responsible for transmitting information...
Sphingolipid metabolites regulate cell fate by acting on specific cellular targets. We used affinity...
Reversible protein phosphorylation plays a crucial role in regulating cell signaling. In normal cell...
Sphingosine kinase 1 (SK1) is an important regulator of cellular signaling that has been implicated ...
The phosphorylation and dephosphorylation of proteins by kinases and phosphatases constitute an esse...
Summary: Despite its low cellular abundance, phosphotyrosine (pTyr) regulates numerous cell signalin...
The anti-neoplastic sphingolipid analog SH-BC-893 starves cancer cells to death by down-regulating c...
Despite the advances in therapeutics targeting key players that drive cancer metabolism, clinical be...
Sphingolipids (SLs) are essential components of cell membranes and are broad-range bioactive signali...
Sphingolipids are found in all kingdoms of life. In mammals, sphingolipids regulate multiple cellula...
Sphingolipids (SLs) are essential components of cell membranes and are broad-range bioactive signali...
Sphingolipids are found in all kingdoms of life. In mammals, sphingolipids regulate multiple cellula...
[[abstract]]There are a large number of signalling pathways responsible for transmitting information...
Sphingolipid metabolites regulate cell fate by acting on specific cellular targets. We used affinity...
[[abstract]]There are a large number of signalling pathways responsible for transmitting information...
[[abstract]]There are a large number of signalling pathways responsible for transmitting information...
Sphingolipid metabolites regulate cell fate by acting on specific cellular targets. We used affinity...
Reversible protein phosphorylation plays a crucial role in regulating cell signaling. In normal cell...
Sphingosine kinase 1 (SK1) is an important regulator of cellular signaling that has been implicated ...
The phosphorylation and dephosphorylation of proteins by kinases and phosphatases constitute an esse...
Summary: Despite its low cellular abundance, phosphotyrosine (pTyr) regulates numerous cell signalin...