Funding: The first and second authors wish to acknowledge support from EPSRC grant EP/R032866/1 received during the editing process of this article. The fourth author would like to thank St. Andrews University for its hospitality during the Workshop on the Extended Family of Thompson’s Groups in 2014, and acknowledges the support of DySYRF (Anillo Project 1103, CONICYT) and Fondecyt’s project 1120131. The fifth author was partly supported by Leverhulme Trust Research Project Grant RPG-2017-159.We characterise the automorphism groups of the Higman groups Gn,r as groups of specific homeomorphisms of Cantor spaces Cn,r, through the use of Rubin's theorem. This continues a thread of research begun by Brin, and extended later by Brin and Guzmán:...