Evidence of the essential role played by Sox3 in cell proliferation and cancer survival is increasing, highlighting the importance of understanding the mechanisms that regulate the function of the Sox3 protein. It has been shown that Sox3 plays a crucial role in embryonic and adult neural stem cells by slowing down proliferation to regulate the stem cells state. Sox3 exerts these functions by working as transcriptional activator and repressor of target genes. It is still not clear how these two functions of Sox3 are regulated. In this study, I was interested in understanding how Sox3 can switch between these two functions, investigating whether this change in activity is linked to SUMOylation. Cell biological analyses via alamar blue, c...
AbstractSRY-related HMG box-containing factor 10 (SOX10) is a transcription factor essential for neu...
SUMOylation is a reversible post-translational modification essential for genome stability. Using hi...
Sp3 is a ubiquitous transcription factor closely related to Sp1. Here we show that Sp3 is a target f...
Evidence of the essential role played by Sox3 in cell proliferation and cancer survival is increasin...
Sox2 plays a crucial role in the biology of neural stem cells (NSC) by regulating differentiation an...
SOX6 plays key functions in several developmental processes, including neurogenesis and skeleton for...
AbstractSOX6 plays key functions in several developmental processes, including neurogenesis and skel...
Nanog is a pivotal transcription factor in embryonic stem (ES) cells and is essential for maintainin...
Embryogenesis in vertebrates is regulated by highly complicated signaling networks, which involve va...
<div><p>SUMOylation is a post-translational ubiquitin-like protein modification pathway that regulat...
Understanding the mechanisms of tumorigenesis is critical to identifying new therapeutic targets and...
Small ubiquitin-like modifier (SUMO)ylation is a reversible post-translational modification that pla...
SUMOylation is a post-translational ubiquitin-like protein modification pathway that regulates impor...
An orphan nuclear receptor, Ad4BP/SF-1, is essential for the development and function of steroido...
The transcription factor SOX1 is a key regulator of neural stem cell development, acting to keep neu...
AbstractSRY-related HMG box-containing factor 10 (SOX10) is a transcription factor essential for neu...
SUMOylation is a reversible post-translational modification essential for genome stability. Using hi...
Sp3 is a ubiquitous transcription factor closely related to Sp1. Here we show that Sp3 is a target f...
Evidence of the essential role played by Sox3 in cell proliferation and cancer survival is increasin...
Sox2 plays a crucial role in the biology of neural stem cells (NSC) by regulating differentiation an...
SOX6 plays key functions in several developmental processes, including neurogenesis and skeleton for...
AbstractSOX6 plays key functions in several developmental processes, including neurogenesis and skel...
Nanog is a pivotal transcription factor in embryonic stem (ES) cells and is essential for maintainin...
Embryogenesis in vertebrates is regulated by highly complicated signaling networks, which involve va...
<div><p>SUMOylation is a post-translational ubiquitin-like protein modification pathway that regulat...
Understanding the mechanisms of tumorigenesis is critical to identifying new therapeutic targets and...
Small ubiquitin-like modifier (SUMO)ylation is a reversible post-translational modification that pla...
SUMOylation is a post-translational ubiquitin-like protein modification pathway that regulates impor...
An orphan nuclear receptor, Ad4BP/SF-1, is essential for the development and function of steroido...
The transcription factor SOX1 is a key regulator of neural stem cell development, acting to keep neu...
AbstractSRY-related HMG box-containing factor 10 (SOX10) is a transcription factor essential for neu...
SUMOylation is a reversible post-translational modification essential for genome stability. Using hi...
Sp3 is a ubiquitous transcription factor closely related to Sp1. Here we show that Sp3 is a target f...