Objective We present the statistical analysis plan of a prespecified Tranexamic Acid for Hyperacute Primary Intracerebral Haemorrhage (TICH)-2 sub-study aiming to investigate, if tranexamic acid has a different effect in intracerebral haemorrhage patients with the spot sign on admission compared to spot sign negative patients. The TICH-2 trial recruited above 2000 participants with intracerebral haemorrhage arriving in hospital within 8 h after symptom onset. They were included irrespective of radiological signs of on-going haematoma expansion. Participants were randomised to tranexamic acid versus matching placebo. In this subgroup analysis, we will include all participants in TICH-2 with a computed tomography angiography on admission a...
Tranexamic acid can prevent death due to bleeding after trauma and post-partum haemorrhage. We aimed...
Background Tranexamic acid reduced haematoma expansion and early death, but did not improve function...
Background Tranexamic acid (TXA) reduces death due to bleeding after trauma and post-partum haemorr...
Objective: We present the statistical analysis plan of a prespecified Tranexamic Acid for Hyperacute...
Abstract Objective We present the statistical analysis plan of a prespecified Tranexamic Acid for Hy...
Additional file 2. Power calculationsâpower calculations of primary and secondary outcomes
Background and Purpose:The computed tomography angiography or contrast-enhanced computed tomography ...
Background: Haematoma expansion leads to worse outcome in intracerebral haemorrhage (ICH). Tranexami...
Abstract Rationale Aside from blood pressure lowering, treatment options for intracerebral haemorrha...
Objectives: To test whether administration of the antifibrinolytic drug tranexamic acid (TXA) in pat...
Purpose Haematoma expansion is a devastating complication of intracerebral haemorrhage with no est...
Spontaneous intracerebral haemorrhage is a devastating condition with high morbidity and mortality. ...
Importance: Hyperintense foci on diffusion-weighted imaging (DWI) that are spatially remote from the...
Tranexamic acid can prevent death due to bleeding after trauma and post-partum haemorrhage. We aimed...
Background Tranexamic acid reduced haematoma expansion and early death, but did not improve function...
Background Tranexamic acid (TXA) reduces death due to bleeding after trauma and post-partum haemorr...
Objective: We present the statistical analysis plan of a prespecified Tranexamic Acid for Hyperacute...
Abstract Objective We present the statistical analysis plan of a prespecified Tranexamic Acid for Hy...
Additional file 2. Power calculationsâpower calculations of primary and secondary outcomes
Background and Purpose:The computed tomography angiography or contrast-enhanced computed tomography ...
Background: Haematoma expansion leads to worse outcome in intracerebral haemorrhage (ICH). Tranexami...
Abstract Rationale Aside from blood pressure lowering, treatment options for intracerebral haemorrha...
Objectives: To test whether administration of the antifibrinolytic drug tranexamic acid (TXA) in pat...
Purpose Haematoma expansion is a devastating complication of intracerebral haemorrhage with no est...
Spontaneous intracerebral haemorrhage is a devastating condition with high morbidity and mortality. ...
Importance: Hyperintense foci on diffusion-weighted imaging (DWI) that are spatially remote from the...
Tranexamic acid can prevent death due to bleeding after trauma and post-partum haemorrhage. We aimed...
Background Tranexamic acid reduced haematoma expansion and early death, but did not improve function...
Background Tranexamic acid (TXA) reduces death due to bleeding after trauma and post-partum haemorr...