Lasso peptides are a subclass of ribosomally synthesized and post-translationally modified peptides with a slipknot conformation. With superior thermal stability, protease resistance, and antimicrobial activity, lasso peptides are promising candidates for bioengineering and pharmaceutical applications. To enable high-throughput computational prediction and design of lasso peptides, we developed a software, LassoHTP, for automatic lasso peptide structure construction and modeling. LassoHTP consists of three modules, including the scaffold constructor, mutant generator, and molecular dynamics (MD) simulator. With a user-provided sequence and conformational annotation, LassoHTP can either generate the structure and conformational ensemble as i...
A new lasso peptide, huascopeptin, was isolated following genome-mined discovery of a new biosynthet...
The lasso peptides are a class of ribosomally synthesized peptide natural products with diverse bioa...
SummaryLasso peptides are a large family of natural products that owe their name to a unique structu...
Lasso peptides are a subclass of ribosomally synthesized and post-translationally modified peptides ...
LassoHTP is a computational tool geared towards lasso peptide design and discovery. Major functional...
ConspectusNatural products of peptidic origin often represent a rich source of medically relevant co...
Lasso peptides are a class of natural products that belong to the family of ribosomally‑assembled an...
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing family of n...
Lasso peptides are a family of ribosomally-synthesized and posttranslationally-modified peptides (R...
AbstractThe antimicrobial peptide microcin J25 (MccJ25) is posttranslationally matured from a linear...
Lasso peptides are unique natural products that comprise a class of ribosomally synthesized and post...
Lasso peptides, such as microcin J25, BI-32169, lariatin and capistruin, are a structurally unique a...
Lasso peptides are a class of ribosomally synthesized and post-translationally modified natural prod...
The first part of this dissertation describes the synthesis of peptide-based [1]rotaxanes (lasso pep...
Short peptides can be designed in silico and synthesized through automated techniques, making them a...
A new lasso peptide, huascopeptin, was isolated following genome-mined discovery of a new biosynthet...
The lasso peptides are a class of ribosomally synthesized peptide natural products with diverse bioa...
SummaryLasso peptides are a large family of natural products that owe their name to a unique structu...
Lasso peptides are a subclass of ribosomally synthesized and post-translationally modified peptides ...
LassoHTP is a computational tool geared towards lasso peptide design and discovery. Major functional...
ConspectusNatural products of peptidic origin often represent a rich source of medically relevant co...
Lasso peptides are a class of natural products that belong to the family of ribosomally‑assembled an...
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing family of n...
Lasso peptides are a family of ribosomally-synthesized and posttranslationally-modified peptides (R...
AbstractThe antimicrobial peptide microcin J25 (MccJ25) is posttranslationally matured from a linear...
Lasso peptides are unique natural products that comprise a class of ribosomally synthesized and post...
Lasso peptides, such as microcin J25, BI-32169, lariatin and capistruin, are a structurally unique a...
Lasso peptides are a class of ribosomally synthesized and post-translationally modified natural prod...
The first part of this dissertation describes the synthesis of peptide-based [1]rotaxanes (lasso pep...
Short peptides can be designed in silico and synthesized through automated techniques, making them a...
A new lasso peptide, huascopeptin, was isolated following genome-mined discovery of a new biosynthet...
The lasso peptides are a class of ribosomally synthesized peptide natural products with diverse bioa...
SummaryLasso peptides are a large family of natural products that owe their name to a unique structu...