Study overview.

Mendelian randomization analysis of individual SNPS (with cholesterol in small LDL as the outcome).

Fengyi Zhang (805423)
Yufeng Zhang (195768)
Jiayi Zhang (5470265)
Xin Wang (91924)
Yujie Li (294983)
Wenbo Wang (300277)

February 2024

Mendelian randomization analysis of individual SNPS (with cholesterol in small LDL as the outcome).<...

Using Multivariable Mendelian Randomization to Disentangle the Causal Effects of Lipid Fractions

Stephen Burgess
Daniel F. Freitag
Hassan Khan
Donal N. Gorman
Simon G. Thompson

January 2014

Background: Previous Mendelian randomization studies have suggested that, while low-density lipoprot...

Summary of estimated genetic additive effects of rs4238001 allele T on LDL-C (mg/dL), LDL particle number (nmol/L) and LDL particle size (log nm) under a basic regression model (Model 1).

Ani Manichaikul (110134)
Xin-Qun Wang (713819)
Solomon K. Musani (223808)
David M. Herrington (566215)
Wendy S. Post (228765)
James G. Wilson (113688)
Stephen S. Rich (110262)
Annabelle Rodriguez (742007)

May 2015

Analyses were conducted stratified by race/ethnic group and combined by meta-analysis, for all pa...

Results from Mendelian randomisation analysis on the associations between genetically proxied inhibition of drug targets, reduction of LDLR levels of LDL-c levels, and the levels of lipoprotein A.

Si Fang (14321990)
James Yarmolinsky (739630)
Dipender Gill (5514923)
Caroline J. Bull (8654428)
Claire M. Perks (14321993)
George Davey Smith (7180727)
Tom R. Gaunt (7747922)
Tom G. Richardson (7779047)

January 2023

Estimates are effects equivalent to 1 SD reduction in LDL-c levels or 1 SD reduction in plasma prote...

Relative effects of LDL-C on ischemic stroke and coronary disease A Mendelian randomization study

Valdes-Marquez, E
Parish, S
Clarke, R
Stari, T
Worrall, BB
Hopewell, JC
Slowik, A
Hofman, A
Algra, A
Reiner, AP
Doney, ASF
Gschwendtner, A
Ilinca, A
Giese, A-K
Lindgren, A
Vicente, AM
Norrving, B
Nordestgaard, BG
Mitchell, BD
Psaty, BM
Carty, CL
Sudlow, CLM
Anderson, C
Levi, CR
Satizabal, CL
Palmer, CNA
Gamble, DM
Woo, D
Saleheen, D
Ringelstein, EB
Valdimarsson, EM
Holliday, EG
Davies, G
Chauhan, G
Pasterkamp, G
Boncoraglio, GB
Kuhlenbaeumer, G
Thorleifsson, G
Falcone, GJ
Pare, G
Schmidt, H
Delavaran, H
Markus, HS
Aparicio, HJ
Deary, I
Cotlarciuc, I
Fernandez-Cadenas, I
Meschia, JF
Liu, J
Montaner, J
Pera, J
Cole, J
Attia, JR
Rosand, J
Ferro, JM
Bis, JC
Furie, K
Stefansson, K
Berger, K
Kostulas, K
Rannikmae, K
Ikram, MA
Benn, M
Dichgans, M
Pandolfo, M
Traylor, M
Walters, M
Sale, M
Nalls, MA
Fornage, M
van Zuydam, NR
Sharma, P
Abrantes, P
de Bakker, PIW
Higgins, P
Lichtner, P
Rothwell, PM
Amouyel, P
Yang, Q
Malik, R
Schmidt, R
Lemmens, R
van der Laan, SW
Pulit, SL
Abboud, S
Oliveira, SA
Gretarsdottir, S
Debette, S
Williams, SR
Bevan, S
Kittner, SJ
Seshadri, S
Mosley, T
Battey, TWK
Tatlisumak, T
Thorsteinsdottir, U
Thijs, VNS
Longstreth, WT
Zhao, W
Chen, W-M
Cheng, Y-C

March 2019

OBJECTIVE: To examine the causal relevance of lifelong differences in low-density lipoprotein choles...

Data from: Relative effects of LDL-C on ischaemic stroke & coronary disease: a Mendelian randomization study

Valdes-Marquez, Elsa
Parish, Sarah
Clarke, Robert
Stari, Traiani
Worrall, Bradford B.
Hopewell, Jemma C.

March 2019

Objective: To examine the causal relevance of lifelong differences in LDL-C for ischaemic stroke (IS...

Relative effects of LDL-C on ischemic stroke and coronary disease: A Mendelian randomization study

Valdes-Marque, E
Parish, S
Clarke, R
Stari, T
Worrall, B
METASTROKE Consortium of the ISGC
Hopewell, J

January 2019

Objective To examine the causal relevance of lifelong differences in low-density lipoprotein cholest...

Results from Mendelian randomisation analysis on the associations between genetically proxied inhibition of drug targets, reduction of LDLR levels of LDL-c levels, and body mass index.

Si Fang (14321990)
James Yarmolinsky (739630)
Dipender Gill (5514923)
Caroline J. Bull (8654428)
Claire M. Perks (14321993)
George Davey Smith (7180727)
Tom R. Gaunt (7747922)
Tom G. Richardson (7779047)

January 2023

Estimates are effects equivalent to 1 SD reduction in LDL-c levels or 1 SD reduction in plasma prote...

Applying Mendelian randomization to define the causal relationship between phenotype and disease.

Caroline L. Relton (174120)
George Davey Smith (82619)

February 2013

An example based upon the report of Lintel-Nietschke et al. (2008) <a href="http://www.plosmedici...

Results from Mendelian randomisation analysis on the associations between genetically proxied inhibition of drug targets, reduction of LDLR levels of LDL-c levels, and the levels of testosterone.

Si Fang (14321990)
James Yarmolinsky (739630)
Dipender Gill (5514923)
Caroline J. Bull (8654428)
Claire M. Perks (14321993)
George Davey Smith (7180727)
Tom R. Gaunt (7747922)
Tom G. Richardson (7779047)

January 2023

Estimates are effects equivalent to 1 SD reduction in LDL-c levels or 1 SD reduction in plasma prote...

Relative effects of LDL-C on ischemic stroke and coronary disease: A Mendelian randomization study.

Valdes-Marquez, E.
Parish, S.
Clarke, R.
Stari, T.
Worrall, B.B.
Hopewell, J.C.
METASTROKE Consortium (Lichtner, P.)

January 2019

ObjectiveTo examine the causal relevance of lifelong differences in low-density lipoprotein choleste...

Triglyceride lowering LPL alleles combined with LDL-C lowering alleles are associated with an additively improved lipoprotein profile

Christodoulides, C

January 2021

Aim and objectives: In Mendelian Randomization studies, triglyceride (TG) lowering lipoprotein lipas...

Results from MR analyses to estimate the effect of lipid-lowering therapies and risk factors on overall prostate cancer risk.

Si Fang (14321990)
James Yarmolinsky (739630)
Dipender Gill (5514923)
Caroline J. Bull (8654428)
Claire M. Perks (14321993)
George Davey Smith (7180727)
Tom R. Gaunt (7747922)
Tom G. Richardson (7779047)

January 2023

Effect estimates are odds ratios for prostate cancer per 1 SD reduction in LDL-c proxied using genet...

Lifelong Reduction of LDL-Cholesterol Related to a Common Variant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease—A Mendelian Randomisation Study

Linsel-Nitschke Patrick
Götz Anika
Erdmann Jeanette
Braenne Ingrid
Braund Peter
Hengstenberg Christian
Stark Klaus
Fischer Marcus
Schreiber Stefan
El Mokhtari Nour Eddine
Schaefer Arne
Schrezenmeier Jürgen
Rubin Diana
Hinney Anke
Reinehr Thomas
Roth Christian
Ortlepp Jan
Hanrath Peter
Hall Alistair S.
Mangino Massimo
Lieb Wolfgang
Lamina Claudia
Heid Iris M.
Doering Angela
Gieger Christian
Peters Annette
Meitinger Thomas
Wichmann H.-Erich
König Inke R.
Ziegler Andreas
Kronenberg Florian
Samani Nilesh J.
Schunkert Heribert

August 2008

gene regarding the variability of cholesterol levels and risk of CAD. gene in three European sample...

Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study.

Linsel-Nitschke, P.
Götz, A.
Erdmann, J.
Braenne, I.
Braund, P.
Hengstenberg, C.
Stark, K.
Fischer, M.
Schreiber, S.
El Mokhtari, N.E.
Schaefer, A.
Schrezenmeir, J.
Rubin, D.
Hinney, A.
Reinehr, T.
Roth, C.
Ortlepp, J.
Hanrath, P.
Hall, A.S.
Mangino, M.
Lieb, W.
Lamina, C.
Heid, I.M.
Döring, A.
Gieger, C.
Peters, A.
Meitinger, T.
Wichmann, H.-E.
König, I.R.
Ziegler, A.
Kronenberg, F.
Samani, N.J.
Schunkert, H.
Wellcome Trust Case Consortium (WTCCC) ()
CARDIOGENICS Consortium ()

January 2008

Rare mutations of the low-density lipoprotein receptor gene (LDLR) cause familial hypercholesterolem...

Mendelian randomization analysis of individual SNPS (with cholesterol in small LDL as the outcome).

Fengyi Zhang (805423)
Yufeng Zhang (195768)
Jiayi Zhang (5470265)
Xin Wang (91924)
Yujie Li (294983)
Wenbo Wang (300277)

February 2024

Mendelian randomization analysis of individual SNPS (with cholesterol in small LDL as the outcome).<...

Using Multivariable Mendelian Randomization to Disentangle the Causal Effects of Lipid Fractions

Stephen Burgess
Daniel F. Freitag
Hassan Khan
Donal N. Gorman
Simon G. Thompson

January 2014

Background: Previous Mendelian randomization studies have suggested that, while low-density lipoprot...

Summary of estimated genetic additive effects of rs4238001 allele T on LDL-C (mg/dL), LDL particle number (nmol/L) and LDL particle size (log nm) under a basic regression model (Model 1).

Ani Manichaikul (110134)
Xin-Qun Wang (713819)
Solomon K. Musani (223808)
David M. Herrington (566215)
Wendy S. Post (228765)
James G. Wilson (113688)
Stephen S. Rich (110262)
Annabelle Rodriguez (742007)

May 2015

Analyses were conducted stratified by race/ethnic group and combined by meta-analysis, for all pa...

Results from Mendelian randomisation analysis on the associations between genetically proxied inhibition of drug targets, reduction of LDLR levels of LDL-c levels, and the levels of lipoprotein A.

Si Fang (14321990)
James Yarmolinsky (739630)
Dipender Gill (5514923)
Caroline J. Bull (8654428)
Claire M. Perks (14321993)
George Davey Smith (7180727)
Tom R. Gaunt (7747922)
Tom G. Richardson (7779047)

January 2023

Estimates are effects equivalent to 1 SD reduction in LDL-c levels or 1 SD reduction in plasma prote...

Relative effects of LDL-C on ischemic stroke and coronary disease A Mendelian randomization study

Valdes-Marquez, E
Parish, S
Clarke, R
Stari, T
Worrall, BB
Hopewell, JC
Slowik, A
Hofman, A
Algra, A
Reiner, AP
Doney, ASF
Gschwendtner, A
Ilinca, A
Giese, A-K
Lindgren, A
Vicente, AM
Norrving, B
Nordestgaard, BG
Mitchell, BD
Psaty, BM
Carty, CL
Sudlow, CLM
Anderson, C
Levi, CR
Satizabal, CL
Palmer, CNA
Gamble, DM
Woo, D
Saleheen, D
Ringelstein, EB
Valdimarsson, EM
Holliday, EG
Davies, G
Chauhan, G
Pasterkamp, G
Boncoraglio, GB
Kuhlenbaeumer, G
Thorleifsson, G
Falcone, GJ
Pare, G
Schmidt, H
Delavaran, H
Markus, HS
Aparicio, HJ
Deary, I
Cotlarciuc, I
Fernandez-Cadenas, I
Meschia, JF
Liu, J
Montaner, J
Pera, J
Cole, J
Attia, JR
Rosand, J
Ferro, JM
Bis, JC
Furie, K
Stefansson, K
Berger, K
Kostulas, K
Rannikmae, K
Ikram, MA
Benn, M
Dichgans, M
Pandolfo, M
Traylor, M
Walters, M
Sale, M
Nalls, MA
Fornage, M
van Zuydam, NR
Sharma, P
Abrantes, P
de Bakker, PIW
Higgins, P
Lichtner, P
Rothwell, PM
Amouyel, P
Yang, Q
Malik, R
Schmidt, R
Lemmens, R
van der Laan, SW
Pulit, SL
Abboud, S
Oliveira, SA
Gretarsdottir, S
Debette, S
Williams, SR
Bevan, S
Kittner, SJ
Seshadri, S
Mosley, T
Battey, TWK
Tatlisumak, T
Thorsteinsdottir, U
Thijs, VNS
Longstreth, WT
Zhao, W
Chen, W-M
Cheng, Y-C

March 2019

OBJECTIVE: To examine the causal relevance of lifelong differences in low-density lipoprotein choles...

Data from: Relative effects of LDL-C on ischaemic stroke & coronary disease: a Mendelian randomization study

Valdes-Marquez, Elsa
Parish, Sarah
Clarke, Robert
Stari, Traiani
Worrall, Bradford B.
Hopewell, Jemma C.

March 2019

Objective: To examine the causal relevance of lifelong differences in LDL-C for ischaemic stroke (IS...

Relative effects of LDL-C on ischemic stroke and coronary disease: A Mendelian randomization study

Valdes-Marque, E
Parish, S
Clarke, R
Stari, T
Worrall, B
METASTROKE Consortium of the ISGC
Hopewell, J

January 2019

Objective To examine the causal relevance of lifelong differences in low-density lipoprotein cholest...

Results from Mendelian randomisation analysis on the associations between genetically proxied inhibition of drug targets, reduction of LDLR levels of LDL-c levels, and body mass index.

Si Fang (14321990)
James Yarmolinsky (739630)
Dipender Gill (5514923)
Caroline J. Bull (8654428)
Claire M. Perks (14321993)
George Davey Smith (7180727)
Tom R. Gaunt (7747922)
Tom G. Richardson (7779047)

January 2023

Estimates are effects equivalent to 1 SD reduction in LDL-c levels or 1 SD reduction in plasma prote...

Applying Mendelian randomization to define the causal relationship between phenotype and disease.

Caroline L. Relton (174120)
George Davey Smith (82619)

February 2013

An example based upon the report of Lintel-Nietschke et al. (2008) <a href="http://www.plosmedici...

Results from Mendelian randomisation analysis on the associations between genetically proxied inhibition of drug targets, reduction of LDLR levels of LDL-c levels, and the levels of testosterone.

Si Fang (14321990)
James Yarmolinsky (739630)
Dipender Gill (5514923)
Caroline J. Bull (8654428)
Claire M. Perks (14321993)
George Davey Smith (7180727)
Tom R. Gaunt (7747922)
Tom G. Richardson (7779047)

January 2023

Estimates are effects equivalent to 1 SD reduction in LDL-c levels or 1 SD reduction in plasma prote...

Relative effects of LDL-C on ischemic stroke and coronary disease: A Mendelian randomization study.

Valdes-Marquez, E.
Parish, S.
Clarke, R.
Stari, T.
Worrall, B.B.
Hopewell, J.C.
METASTROKE Consortium (Lichtner, P.)

January 2019

ObjectiveTo examine the causal relevance of lifelong differences in low-density lipoprotein choleste...

Triglyceride lowering LPL alleles combined with LDL-C lowering alleles are associated with an additively improved lipoprotein profile

Christodoulides, C

January 2021

Aim and objectives: In Mendelian Randomization studies, triglyceride (TG) lowering lipoprotein lipas...

Results from MR analyses to estimate the effect of lipid-lowering therapies and risk factors on overall prostate cancer risk.

Si Fang (14321990)
James Yarmolinsky (739630)
Dipender Gill (5514923)
Caroline J. Bull (8654428)
Claire M. Perks (14321993)
George Davey Smith (7180727)
Tom R. Gaunt (7747922)
Tom G. Richardson (7779047)

January 2023

Effect estimates are odds ratios for prostate cancer per 1 SD reduction in LDL-c proxied using genet...

Lifelong Reduction of LDL-Cholesterol Related to a Common Variant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease—A Mendelian Randomisation Study

Linsel-Nitschke Patrick
Götz Anika
Erdmann Jeanette
Braenne Ingrid
Braund Peter
Hengstenberg Christian
Stark Klaus
Fischer Marcus
Schreiber Stefan
El Mokhtari Nour Eddine
Schaefer Arne
Schrezenmeier Jürgen
Rubin Diana
Hinney Anke
Reinehr Thomas
Roth Christian
Ortlepp Jan
Hanrath Peter
Hall Alistair S.
Mangino Massimo
Lieb Wolfgang
Lamina Claudia
Heid Iris M.
Doering Angela
Gieger Christian
Peters Annette
Meitinger Thomas
Wichmann H.-Erich
König Inke R.
Ziegler Andreas
Kronenberg Florian
Samani Nilesh J.
Schunkert Heribert

August 2008

gene regarding the variability of cholesterol levels and risk of CAD. gene in three European sample...

Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study.

Linsel-Nitschke, P.
Götz, A.
Erdmann, J.
Braenne, I.
Braund, P.
Hengstenberg, C.
Stark, K.
Fischer, M.
Schreiber, S.
El Mokhtari, N.E.
Schaefer, A.
Schrezenmeir, J.
Rubin, D.
Hinney, A.
Reinehr, T.
Roth, C.
Ortlepp, J.
Hanrath, P.
Hall, A.S.
Mangino, M.
Lieb, W.
Lamina, C.
Heid, I.M.
Döring, A.
Gieger, C.
Peters, A.
Meitinger, T.
Wichmann, H.-E.
König, I.R.
Ziegler, A.
Kronenberg, F.
Samani, N.J.
Schunkert, H.
Wellcome Trust Case Consortium (WTCCC) ()
CARDIOGENICS Consortium ()

January 2008

Rare mutations of the low-density lipoprotein receptor gene (LDLR) cause familial hypercholesterolem...

Mendelian randomization analysis of individual SNPS (with cholesterol in small LDL as the outcome).

Fengyi Zhang (805423)
Yufeng Zhang (195768)
Jiayi Zhang (5470265)
Xin Wang (91924)
Yujie Li (294983)
Wenbo Wang (300277)

February 2024

Mendelian randomization analysis of individual SNPS (with cholesterol in small LDL as the outcome).<...

Using Multivariable Mendelian Randomization to Disentangle the Causal Effects of Lipid Fractions

Stephen Burgess
Daniel F. Freitag
Hassan Khan
Donal N. Gorman
Simon G. Thompson

January 2014

Background: Previous Mendelian randomization studies have suggested that, while low-density lipoprot...

Summary of estimated genetic additive effects of rs4238001 allele T on LDL-C (mg/dL), LDL particle number (nmol/L) and LDL particle size (log nm) under a basic regression model (Model 1).

Ani Manichaikul (110134)
Xin-Qun Wang (713819)
Solomon K. Musani (223808)
David M. Herrington (566215)
Wendy S. Post (228765)
James G. Wilson (113688)
Stephen S. Rich (110262)
Annabelle Rodriguez (742007)

May 2015

Analyses were conducted stratified by race/ethnic group and combined by meta-analysis, for all pa...

Abstract

Extracted data

Study overview.

Abstract

Extracted data

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