Accuracy of the minor allele frequency (MAF) estimates per locus determined with THE REAL McCOIL approach.

The accuracy of MAF estimates per locus is defined as the differences between estimated and true MAF per locus. While null values highlight accurate MAF estimates per locus (indicated by a dashed black horizontal line), the positive and negative values highlight over- and under-estimation, respectively. For each category, the horizontal central solid line represents the median, the diamond represents the mean, the box represents the interquartile range (IQR) from the 25th to 75th centiles, the whiskers indicate the most extreme data point which is no more than 1.5 times the interquartile range from the box, and the dots show the outliers, i.e. the points beyond the whiskers. The dark and light green colors indicate respectively MAF estimations made without and with a measurement model (Fig 2). Upper, middle, and lower panels correspond to simulations under low-, moderate-, and high-transmission settings, respectively (S1 and S2 Tables). (EPS)