MageA6 expression protects MageA11 from proteasome-dependent degradation
- Laiseca, Julieta Eva
- Ladelfa, Maria Fatima
- Cotignola, Javier Hernan
- Peche, Leticia Y.
- Pascucci, Franco Andrés
- Castaño, Bryan Alain Alexis
- Galigniana, Mario Daniel
- Schneider, Claudio
- Monte, Martin
DOIAbstract
MAGE-A (Melanoma Antigen Genes-A) are tumor-associated proteins with expression in a broad spectrum of human tumors and normal germ cells. MAGE-A gene expression and function are being increasingly investigated to better understand the mechanisms by which MAGE proteins collaborate in tumorigenesis and whether their detection could be useful for disease prognosis purposes. Alterations in epigenetic mechanisms involved in MAGE gene silencing cause their frequent co-expression in tumor cells. Here, we have analyzed the effect of MAGE-A gene co-expression and our results suggest that MageA6 can potentiate the androgen receptor (AR) co-activation function of MageA11. Database search confirmed that MageA11 and MageA6 are co-expressed in human pro...
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