Background: Smoking has shown interactions with bladder cancer (BC) genetic variants, especially N-acetyltransferase-2 (NAT2), a tobacco smoke metabolism gene, on BC risk. The interactions by disease aggressiveness are unknown. Methods: We investigated the interaction between smoking and 18 single nucleotide polymorphisms (SNPs) for BC, individually and in a genetic risk score (GRS), on urothelial cancer (UC) risk including BC. We analysed data from 25,453 individuals with 520 incident UCs during follow-up, 339 non-aggressive (non-fatal, non-muscle invasive) and 163 aggressive (all other) UCs. Hazard ratios (HRs), absolute risks and additive and multiplicative interactions for two-by-two combinations of never/ever smoking with low/high gene...
[[abstract]]Cigarette smoking, aromatic amines and ionizing radiation are known carcinogens of bladd...
BACKGROUND Bladder cancer is the fifth most common cancer in the United States and smoking is the...
Tobacco smoking is the most important and well-established bladder cancer risk factor and a rich sou...
Background: Smoking has shown interactions with bladder cancer (BC) genetic variants, especially N-a...
Bladder cancer is a complex disease with known environmental and genetic risk factors. We performed ...
Background: Urinary bladder cancer (UBC) is one of few cancers with an established gene-environment ...
International audienceBladder cancer (BC) is the 6th most common cancer worldwide, with tobacco smok...
D ow nloaded from Associations between bladder cancer risk and NAT2 and GSTM1 polymorphisms have eme...
ABSTRACT The relationship between smoking and bladder cancer risk and whether such effect is modifie...
International audienceCancer epidemiology has undergone marked development since the nineteen-fiftie...
Cancer is a common multifactor human disease resulting from complex interactions between many geneti...
Little is known whether genetic variants identified in genome-wide association studi...
Contains fulltext : 181627.pdf (Publisher’s version ) (Open Access)Little is known...
Tobacco use is an established cause of bladder cancer. The ability to detoxify aromatic amines, whic...
Purpose: This study was conducted to examine: 1) whether the NAT2 genotypes are risk factors for bla...
[[abstract]]Cigarette smoking, aromatic amines and ionizing radiation are known carcinogens of bladd...
BACKGROUND Bladder cancer is the fifth most common cancer in the United States and smoking is the...
Tobacco smoking is the most important and well-established bladder cancer risk factor and a rich sou...
Background: Smoking has shown interactions with bladder cancer (BC) genetic variants, especially N-a...
Bladder cancer is a complex disease with known environmental and genetic risk factors. We performed ...
Background: Urinary bladder cancer (UBC) is one of few cancers with an established gene-environment ...
International audienceBladder cancer (BC) is the 6th most common cancer worldwide, with tobacco smok...
D ow nloaded from Associations between bladder cancer risk and NAT2 and GSTM1 polymorphisms have eme...
ABSTRACT The relationship between smoking and bladder cancer risk and whether such effect is modifie...
International audienceCancer epidemiology has undergone marked development since the nineteen-fiftie...
Cancer is a common multifactor human disease resulting from complex interactions between many geneti...
Little is known whether genetic variants identified in genome-wide association studi...
Contains fulltext : 181627.pdf (Publisher’s version ) (Open Access)Little is known...
Tobacco use is an established cause of bladder cancer. The ability to detoxify aromatic amines, whic...
Purpose: This study was conducted to examine: 1) whether the NAT2 genotypes are risk factors for bla...
[[abstract]]Cigarette smoking, aromatic amines and ionizing radiation are known carcinogens of bladd...
BACKGROUND Bladder cancer is the fifth most common cancer in the United States and smoking is the...
Tobacco smoking is the most important and well-established bladder cancer risk factor and a rich sou...