High soluble transferrin receptor in patients with heart failure: a measure of iron deficiency and a strong predictor of mortality
- Sierpinski, Radoslaw
- Josiak, Krystian
- Suchocki, Tomasz
- Wojtas-Polc, Katarzyna
- Mazur, Grzegorz
- Butrym, Aleksandra
- Rozentryt, Piotr
- van Der Meer, Peter
- Comin-Colet, Josep
- von Haehling, Stephan
- Kosmala, Wojciech
- Przewlocka-Kosmala, Monika
- Banasiak, Waldemar
- Nowak, Jolanta
- Voors, Adriaan A.
- Anker, Stefan D.
- Cleland, John G. F.
- Ponikowski, Piotr
- Jankowska, Ewa A.
DOIAbstract
Aims Iron deficiency (ID) is frequent in heart failure (HF), linked with exercise intolerance and poor prognosis. Intravenous iron repletion improves clinical status in HF patients with left ventricular ejection fraction (LVEF) Methods and results Bone marrow was stained for iron in 30 patients with ischaemic HF with LVEF = 1.25 mg/L in 47% of HF patients, in 56% and 46% of anaemics and non-anaemics, respectively (P = 1.41 mg/L was the optimal threshold for predicting 3-year mortality, independent of other established variables. Conclusions High serum sTfR accurately reflects depleted iron stores in bone marrow in patients with HF, and identifies those with a high 3-year mortality
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