Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia
- Whiteside, DJ
- Malpetti, M
- Jones, PS
- Ghosh, BCP
- Coyle‐Gilchrist, I
- van Swieten, JC
- Seelaar, H
- Jiskoot, L
- Borroni, B
- Sanchez‐Valle, R
- Moreno, F
- Verdelho, A
- Freedman, M
- Keren, R
- Black, S
- Mitchell, S
- Shoesmith, C
- Synofzik, M
- Bartha, R
- Balasa, M
- Rademakers, R
- Finger, E
- Poos, J
- Maruta, C
- Papma, JM
- Giannini, L
- van Minkelen, R
- Pijnenburg, Y
- Ferrari, C
- Polito, C
- Brice, A
- Lombardi, G
- Colliot, O
- Bessi, V
- Bargalló, N
- Ferreira, CB
- Veldsman, M
- Andersson, C
- Thonberg, H
- Öijerstedt, L
- Jelic, V
- Thompson, P
- Langheinrich, T
- Sayah, S
- Miltenberger, G
- Laforce, R
- Simões do Couto, F
- Gabilondo, A
- Gorostidi, A
- Zetterberg, H
- Villanua, J
- Funkiewiez, A
- Cañada, M
- Tainta, M
- Prix, C
- Zulaica, M
- Barandiaran, M
- Alves, P
- Bender, B
- Graff, C
- Wilke, C
- Tartaglia, MC
- Graf, L
- Vogels, A
- Rinaldi, D
- Wlasich, E
- Vandenbulcke, M
- Van Damme, P
- Bruffaerts, R
- Poesen, K
- Rosa‐Neto, P
- Gauthier, S
- Camuzat, A
- Wagemann, O
- Todd, E
- Loosli, S
- Galimberti, D
- Schönecker, S
- Tang‐Wai, D
- Hoegen, T
- Vandenberghe, R
- Lombardi, J
- Anderl‐Straub, S
- Rollin, A
- Kuchcinski, G
- Bertoux, M
- Lebouvier, T
- Benotmane, H
- Deramecourt, V
- Samra, K
- Santiago, B
- Masellis, M
- de Mendonça, A
- Duro, D
- Leitão, MJ
- Almeida, MR
- Tábuas‐Pereira, M
- Afonso, S
- Engel, A
- Polyakova, M
- Russell, LL
- Tagliavini, F
- Butler, CR
- Santana, I
- Ber, IL
- Gerhard, A
- Olives, J
- Ducharme, S
- Swift, IJ
- Levin, J
- Danek, A
- Bocchetta, M
- Otto, M
- Sorbi, S
- Pasquier, F
- Bouzigues, A
- Russell, LL
- Rohrer, JD
- Redaelli, V
- Rowe, JB
- Rittman, T
- Nicholas, J
- Shafei, R
- Esteve, AS
- Nelson, A
- Bouzigues, A
- Heller, C
- Greaves, CV
- Cash, D
- Thomas, DL
- Convery, RS
- Lladó, A
- Timberlake, C
- Cope, T
- Rittman, T
- Bertrand, A
- Benussi, A
- Rogaeva, E
- Premi, E
- Gasparotti, R
- Archetti, S
- Gazzina, S
- Cantoni, V
- Arighi, A
- Antonell, A
- Fenoglio, C
- Borrego‐Ecija, S
- Scarpini, E
- Fumagalli, G
- Castelo‐Branco, M
- Borracci, V
- Rossi, G
- Giaccone, G
- Di Fede, G
- Caroppo, P
- Tiraboschi, P
- Prioni, S
DOIAbstract
Copyright © 2022 The Authors. Introduction We tested whether changes in functional networks predict cognitive decline and conversion from the presymptomatic prodrome to symptomatic disease in familial frontotemporal dementia (FTD). Methods For hypothesis generation, 36 participants with behavioral variant FTD (bvFTD) and 34 controls were recruited from one site. For hypothesis testing, we studied 198 symptomatic FTD mutation carriers, 341 presymptomatic mutation carriers, and 329 family members without mutations. We compared functional network dynamics between groups, with clinical severity and with longitudinal clinical progression. Results: We identified a characteristic pattern of dynamic network changes in FTD, which cor...
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