Background Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined that testosterone increased glucose uptake-via AMP-activated protein kinase (AMPK)-after acute treatment in cardiomyocytes. However, whether elevated glucose uptake is involved in long-term changes of glucose metabolism or is required during cardiomyocyte growth remained unknown. In this study, we hypothesized that glucose uptake and glycolysis increase in testosterone-treated cardiomyocytes through AMPK and androgen receptor (AR). Methods Cultured cardiomyocytes were stimulated with 100 nM testosterone for 24 h, and hypertrop...
Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomi...
Testosterone deficiency is common in men with cardiovascular disease (CVD), and randomized placebo-c...
Abstract Background: Impaired angiogenesis in cardiac tissue is a major complication of diabetes. P...
Background Testosterone regulates nutrient and energy balance to maintain protein synthesis and meta...
Elevated testosterone concentrations induce cardiac hypertrophy but the molecular mechanisms are poo...
Testosterone is known to induce cardiac hypertrophy through androgen receptor (AR)-dependent and -in...
Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk bet...
<div><p>Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted cross...
Cytochrome P450 mono-oxygenases (CYP) play an essential role in steroid metabolism, and there is spe...
Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk bet...
Despite the importance of testosterone as a metabolic hormone, its effects on myocardial metabolism ...
BackgroundType 2 Diabetes Mellitus (T2DM) is characterised by hyperglycemia due to the incidence of ...
<p>Cardiac myocytes were stimulated with 100 nM testosterone for 15, 30, 60, 90, and 120 min and sub...
While androgens generally have been associated with an increased cardiovascular risk, recent studies...
Androgens are associated with important effects on the heart, such as hypertrophy or apoptosis. Thes...
Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomi...
Testosterone deficiency is common in men with cardiovascular disease (CVD), and randomized placebo-c...
Abstract Background: Impaired angiogenesis in cardiac tissue is a major complication of diabetes. P...
Background Testosterone regulates nutrient and energy balance to maintain protein synthesis and meta...
Elevated testosterone concentrations induce cardiac hypertrophy but the molecular mechanisms are poo...
Testosterone is known to induce cardiac hypertrophy through androgen receptor (AR)-dependent and -in...
Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk bet...
<div><p>Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted cross...
Cytochrome P450 mono-oxygenases (CYP) play an essential role in steroid metabolism, and there is spe...
Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk bet...
Despite the importance of testosterone as a metabolic hormone, its effects on myocardial metabolism ...
BackgroundType 2 Diabetes Mellitus (T2DM) is characterised by hyperglycemia due to the incidence of ...
<p>Cardiac myocytes were stimulated with 100 nM testosterone for 15, 30, 60, 90, and 120 min and sub...
While androgens generally have been associated with an increased cardiovascular risk, recent studies...
Androgens are associated with important effects on the heart, such as hypertrophy or apoptosis. Thes...
Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomi...
Testosterone deficiency is common in men with cardiovascular disease (CVD), and randomized placebo-c...
Abstract Background: Impaired angiogenesis in cardiac tissue is a major complication of diabetes. P...