Manufacturing process variation is dramatically becoming one of the most important challenges related to power and performance optimization for sub-90nm CMOS technologies. Process variability impacts the optimization of the target system metrics, that is, performance and energy consumption by introducing fluctuations and unpredictability. Besides, it impacts the parametric yield of the chip with respect to application level constraints by reducing the number of devices working within normal operating conditions. The impact of variability on systems with stringent application-specific requirements (such as portable multimedia and critical embedded systems) is much greater than on general-purpose systems given the emphasis on predictability ...