The GPHN gene codes for gephyrin, a key scaffolding protein in the neuronal postsynaptic membrane, responsible for the clustering and localization of glycine and GABA receptors at inhibitory synapses. Gephyrin has well-established functional links with several synaptic proteins that have been implicated in genetic risk for neurodevelopmental disorders such as autism spectrum disorder (ASD), schizophrenia and epilepsy including the neuroligins (NLGN2, NLGN4), the neurexins (NRXN1, NRXN2, NRXN3) and collybistin (ARHGEF9). Moreover, temporal lobe epilepsy has been linked to abnormally spliced GPHN mRNA lacking exons encoding the G-domain of the gephyrin protein, potentially arising due to cellular stress associated with epileptogenesis such as...
Glycine receptors (GlyRs) and specific subtypes of GABA(A) receptors are clustered at synapses by th...
Glycine receptors (GlyRs) and specific subtypes of GABAA receptors are clustered at synapses by the ...
Abstract To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise ...
The GPHN gene codes for gephyrin, a key scaffolding protein in the neuronal postsynaptic membrane, r...
Gephyrin is a postsynaptic scaffolding protein, essential for the clustering of glycine and gamma-am...
Rare exonic deletions implicate the synaptic organizer Gephyrin (GPHN) in risk for autism, schizophr...
Synaptic inhibition is essential for shaping the dynamics of neuronal networks, and aberrant inhibit...
Gephyrin (GPHN) is an organizational protein that clusters and localizes the inhibitory glycine (Gly...
International audienceGephyrin ( GPHN ) regulates the clustering of postsynaptic components at inhib...
Inhibitory synapse diversity is supported by multiple classes of interneurons with distinct morpholo...
International audienceSynaptic inhibition is essential for shaping the dynamics of neuronal networks...
GABAA and glycine receptors are clustered at inhibitory synapses via interactions with the scaffoldi...
Clustering of inhibitory -aminobutyric acidA (GABAA) and glycine receptors at synapses is thought to...
Clustering of inhibitory -aminobutyric acidA (GABAA) and glycine receptors at synapses is thought to...
Schizophrenia (SZ) and autism spectrum disorders (ASDs) are complex neurodevelopmental disorders tha...
Glycine receptors (GlyRs) and specific subtypes of GABA(A) receptors are clustered at synapses by th...
Glycine receptors (GlyRs) and specific subtypes of GABAA receptors are clustered at synapses by the ...
Abstract To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise ...
The GPHN gene codes for gephyrin, a key scaffolding protein in the neuronal postsynaptic membrane, r...
Gephyrin is a postsynaptic scaffolding protein, essential for the clustering of glycine and gamma-am...
Rare exonic deletions implicate the synaptic organizer Gephyrin (GPHN) in risk for autism, schizophr...
Synaptic inhibition is essential for shaping the dynamics of neuronal networks, and aberrant inhibit...
Gephyrin (GPHN) is an organizational protein that clusters and localizes the inhibitory glycine (Gly...
International audienceGephyrin ( GPHN ) regulates the clustering of postsynaptic components at inhib...
Inhibitory synapse diversity is supported by multiple classes of interneurons with distinct morpholo...
International audienceSynaptic inhibition is essential for shaping the dynamics of neuronal networks...
GABAA and glycine receptors are clustered at inhibitory synapses via interactions with the scaffoldi...
Clustering of inhibitory -aminobutyric acidA (GABAA) and glycine receptors at synapses is thought to...
Clustering of inhibitory -aminobutyric acidA (GABAA) and glycine receptors at synapses is thought to...
Schizophrenia (SZ) and autism spectrum disorders (ASDs) are complex neurodevelopmental disorders tha...
Glycine receptors (GlyRs) and specific subtypes of GABA(A) receptors are clustered at synapses by th...
Glycine receptors (GlyRs) and specific subtypes of GABAA receptors are clustered at synapses by the ...
Abstract To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise ...