A New Method for the Preparation of 1,5-Diynes. Synthesis of (4E,6Z,10Z)-4,6,10-Hexadecatrien-1-ol, the Pheromone Component of the Cocoa Pod Borer Moth Conopomorpha cramerella

A new method for the synthesis of 1,5-diynes, from the reaction of 1,3-dilithiopropyne and propargyl chlorides, was developed. This new methodology was used to prepare (4E,6Z,10Z)-4,6,10-hexadecatrien-1-ol, one of the pheromone components of the cocoa pod borer moth Conopomorpha cramerella, in 51% overall yield.Universidad de Costa RicaConsejo Nacional de Investigaciones Cientıíficas y Tecnológicas (CONICIT)The Third World Academy of ScienceUniversidad de Santiago de CompostelaUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Químic