A new 3-step approach to imaging infectious and inflammatory foci was developed and optimized in a rat model. The approach relies on the nonspecific localization of an anti-diethylenetriaminepentaacetic acid (DTPA) antibody in inflamed tissue. In this study, the 3-step strategy was optimized by selecting the most suitable radiolabeled hapten and tuning the dosing schedule. METHODS: Wistar rats with Staphylococcus aureus infection in the left calf muscle were primed with the anti-DTPA antibody DTIn-1 (0.67, 2, or 6 nmol per rat). In the second step (1-24 h later), the anti-DTPA activity in the circulation was blocked with unlabeled bovine serum albumin DTPA-In (0.3, 1, or 3 nmol per rat). In the third step (5-30 min later), the radiolabeled ...
Introduction: This study was launched to evaluate the sensitivity and specificity of 99mTc-Ciproflox...
Synthetic antimicrobial peptide fragment, 99mTc-Ubiquicidin 29–41, is shown to be sensitive and also...
99mTc-ubiquicidin (UBI) 29-41 is under clinical evaluation for discrimination between bacterial infe...
A new 3-step approach to imaging infectious and inflammatory foci was developed and optimized in a r...
Background: Detection and identification of infection from sterile inflammation foci has a crucial r...
Although several proteins have been proposed and tested for scintigraphic detection of infection, th...
International audienceAbstract There is a need for new targets to specifically localize inflammatory...
INTRODUCTION: A zinc-dipicolylamine analog (Zn-DPA) conjugated with a fluorophore (PSVue(R)794) has ...
A radioimaging approach for the detection of endocarditis has been investigated using two-step preta...
The purpose of this study was to evaluate the localization of positron emission tomography (PET) tra...
The aim of this study was to evaluate Tc-99m labeled human beta-defensin-1 (HBD-1) for discriminatio...
Objective: Many radiopharmaceuticals have been evaluated extensively in both preclinical and clinica...
A radioimaging approach for the detection of endocarditis has been investigated using two-step preta...
Three immunoglobulin molecules were evaluated as infection imaging agents in a rat model of S. aurea...
Deep-seated bacterial infections caused by pathogens such as Staphylococcus aureus are difficult to ...
Introduction: This study was launched to evaluate the sensitivity and specificity of 99mTc-Ciproflox...
Synthetic antimicrobial peptide fragment, 99mTc-Ubiquicidin 29–41, is shown to be sensitive and also...
99mTc-ubiquicidin (UBI) 29-41 is under clinical evaluation for discrimination between bacterial infe...
A new 3-step approach to imaging infectious and inflammatory foci was developed and optimized in a r...
Background: Detection and identification of infection from sterile inflammation foci has a crucial r...
Although several proteins have been proposed and tested for scintigraphic detection of infection, th...
International audienceAbstract There is a need for new targets to specifically localize inflammatory...
INTRODUCTION: A zinc-dipicolylamine analog (Zn-DPA) conjugated with a fluorophore (PSVue(R)794) has ...
A radioimaging approach for the detection of endocarditis has been investigated using two-step preta...
The purpose of this study was to evaluate the localization of positron emission tomography (PET) tra...
The aim of this study was to evaluate Tc-99m labeled human beta-defensin-1 (HBD-1) for discriminatio...
Objective: Many radiopharmaceuticals have been evaluated extensively in both preclinical and clinica...
A radioimaging approach for the detection of endocarditis has been investigated using two-step preta...
Three immunoglobulin molecules were evaluated as infection imaging agents in a rat model of S. aurea...
Deep-seated bacterial infections caused by pathogens such as Staphylococcus aureus are difficult to ...
Introduction: This study was launched to evaluate the sensitivity and specificity of 99mTc-Ciproflox...
Synthetic antimicrobial peptide fragment, 99mTc-Ubiquicidin 29–41, is shown to be sensitive and also...
99mTc-ubiquicidin (UBI) 29-41 is under clinical evaluation for discrimination between bacterial infe...