Methotrexate and leflunomide are both effective drugs in the treatment of patients with rheumatoid arthritis. Methotrexate has been available for many years, whereas leflunomide is a relatively new drug. Several large trials describing its efficacy and safety in comparison with both sulfasalazine and methotrexate and with placebo have been published recently. It appears that leflunomide is approximately equally effective as sulfasalazine and methotrexate. New data are also available on the mechanism of action of leflunomide especially. This drug probably acts as an immunomodulatory agent by interfering with the de novo synthesis of pyrimidines
Background: Several new drugs for rheumatoid arthritis are available including leflunomide. Comparat...
<p>Treatment of rheumatoid arthritis (RA) patients is based on conventional background therapy. This...
MTX has long been considered as the anchor drug in RA treatment, however given, its high failure rat...
In order to compare the efficacy and toxicity of methotrexate and leflunomide for the treatment of r...
Leflunomide is a disease-modifying antirheumatic drug(DMARD) approved by the Food and Drug Adminis-t...
Leflunomide is a novel, isoxazol based disease-modifying anti-rheumatic drug (DMARD) for the treatme...
1.1 Hintergrund und Ziele In die tägliche rheumatologische Praxis hat die Kombination von Leflunomid...
Objectives. To determine, by consensus, the optimal use of leflunomide in rheumatoid arthritis (RA),...
To compare the efficacy and safety of leflunomide (LEF)-anti-TNF-alpha combination therapy to methot...
Several smaller retrospective case series have concluded that leflunomide (LEF) in combination with ...
Contains fulltext : 57598.pdf (publisher's version ) (Closed access)In most studie...
In agreement with EULAR recommendations, a DMARD in combination with a biotherapy is the reference t...
Modern data about possibilities and perspectives of tumor necrosis factor blocking agents and leflun...
In agreement with EULAR recommendations, a DMARD in combination with a biotherapy is the reference t...
Objective To determine the real-life efficacy, safety, and drug-retention rates of leflunomide (LEF)...
Background: Several new drugs for rheumatoid arthritis are available including leflunomide. Comparat...
<p>Treatment of rheumatoid arthritis (RA) patients is based on conventional background therapy. This...
MTX has long been considered as the anchor drug in RA treatment, however given, its high failure rat...
In order to compare the efficacy and toxicity of methotrexate and leflunomide for the treatment of r...
Leflunomide is a disease-modifying antirheumatic drug(DMARD) approved by the Food and Drug Adminis-t...
Leflunomide is a novel, isoxazol based disease-modifying anti-rheumatic drug (DMARD) for the treatme...
1.1 Hintergrund und Ziele In die tägliche rheumatologische Praxis hat die Kombination von Leflunomid...
Objectives. To determine, by consensus, the optimal use of leflunomide in rheumatoid arthritis (RA),...
To compare the efficacy and safety of leflunomide (LEF)-anti-TNF-alpha combination therapy to methot...
Several smaller retrospective case series have concluded that leflunomide (LEF) in combination with ...
Contains fulltext : 57598.pdf (publisher's version ) (Closed access)In most studie...
In agreement with EULAR recommendations, a DMARD in combination with a biotherapy is the reference t...
Modern data about possibilities and perspectives of tumor necrosis factor blocking agents and leflun...
In agreement with EULAR recommendations, a DMARD in combination with a biotherapy is the reference t...
Objective To determine the real-life efficacy, safety, and drug-retention rates of leflunomide (LEF)...
Background: Several new drugs for rheumatoid arthritis are available including leflunomide. Comparat...
<p>Treatment of rheumatoid arthritis (RA) patients is based on conventional background therapy. This...
MTX has long been considered as the anchor drug in RA treatment, however given, its high failure rat...