Association between blood pressure variability and cerebral small-vessel disease: a systematic review and meta-analysis

Tully, P.J.
Yano, Y.
Launer, L.J.
Kario, K.
Nagai, M.
Mooijaart, S.P.
Claassen, J.A.H.R.
Lattanzi, S.
Vincent, A.D.
Tzourio, C.
Variability Blood Pressure Brain

Open link

Publication date

January 2020

DOI

10.1161/jaha.119.013841

Publisher

Ovid Technologies (Wolters Kluwer Health)

Abstract

BackgroundResearch links blood pressure variability (BPV) with stroke; however, the association with cerebral small-vessel disease (CSVD) remains unclear. As BPV and mean blood pressure are interrelated, it remains uncertain whether BPV adds additional information to understanding cerebrovascular morphological characteristics.Methods and ResultsA systematic review was performed from inception until March 3, 2019. Eligibility criteria included population, adults without stroke (<4 weeks); exposure, BPV quantified by any metric over any duration; comparison, (1) low versus high or mean BPV and (2) people with versus without CSVD; and outcomes, (1) CSVD as subcortical infarct, lacunae, white matter hyperintensities, cerebral microbleeds, or en...