This chapter introduces the design-flow of the MULTICUBE project whose main goal is the definition of an automatic multi-objective Design Space Exploration (DSE) framework to be used to tune the parameters of System-on-Chip architectures by taking into account the target set of metrics (e.g. energy, latency, throughput, etc.). One of the important goals of the automatic multi-objective DSE framework is to find design trade-offs that best meet system constraints and cost criteria which are indeed strongly dependent on the target application. A set of heuristic optimisation algorithms have been defined to reduce the overall optimization time by identifying an approximated Pareto set of parameter configurations with respect to a set of sele...