This chapter will present two significant applications of theMULTICUBE design space exploration framework. The first part will present the design space exploration of a low power processor developed by STMicroelectronics by using the modeFRONTIER tool to demonstrate the DSE benefits not only in terms of objective quality, but also in terms of impact on the design process within the corporate environment. The second part will describe the application of RSM models developed within MULTICUBE to a tiled, multiple-instruction, many-core architecture developed by ICT China. Overall, the results have showed that different models can present a trade-off of accuracy versus computational effort. In fact, throughout the evaluation, we observed that...