Running multiple applications optimally in terms of Quality of Service (e.g. performance and power consumption) on embedded multi-core platforms is a huge challenge. Moreover, current applications exhibit unpredictable changes of the environment and workload conditions which makes the task of running them optimally even more difficult. This dynamic trend in application runs will grow even more in future applications. This Chapter presents an automated tool flow which tackles this challenge by a two-step approach: first at design-time, a Design Space Exploration (DSE) tool is coupled with a platform simulator(s) to get optimum operating points for the set of target applications. Secondly, at run-time, a lightweight Run-time Resource Manage...