Middle Permian (Guadalupian) ostracods are described from the Williams Ranch Member of the Cutoff Formation (Roadian) and the McKittrick Canyon Member of the Bell Canyon Formation (Capitanian) from two sections exposed in Culberson County, Guadalupe Mountains, West Texas. Their taxonomy is discussed and adds to the scientific understanding of marine ostracod biodiversity and palaeobiogeography during the Middle Permian. Ostracod assemblages are represented by 51 species of 26 genera and 15 families. Eleven species are newly described: Healdia mckittrickensis Crasquin sp. nov., Healdia cutoffella Crasquin sp. nov., Aurikirkbya guadalupensis Crasquin sp. nov., Hollinella (Hollinella) williamsranchensis Crasquin sp. nov., Geisina culbersonensi...