Caspase-6 (Casp6) is implicated in Alzheimer disease (AD) cognitive impairment and pathology. Hippocampal atrophy is associated with cognitive impairment in AD. Here, a rare functional exonic missense CASP6 single nucleotide polymorphism (SNP), causing the substitution of asparagine with threonine at amino acid 73 in Casp6 (Casp6N73T), was associated with hippocampal subfield CA1 volume preservation. Compared to wild type Casp6 (Casp6WT), recombinant Casp6N73T altered Casp6 proteolysis of natural substrates Lamin A/C and α-Tubulin, but did not alter cleavage of the Ac-VEID-AFC Casp6 peptide substrate. Casp6N73T-transfected HEK293T cells showed elevated Casp6 mRNA levels similar to Casp6WT-transfected cells, but, in contrast to Casp6WT, did ...
The accumulation of amyloid beta (A beta) peptide (Amyloid cascade hypothesis), an APP protein cleav...
The accumulation of amyloid beta (A beta) peptide (Amyloid cascade hypothesis), an APP protein cleav...
The accumulation of amyloid beta (Aβ) peptide (Amyloid cascade hypothesis), an APP protein cleavage ...
Abstract Caspase-6 (Casp6) is implicated in Alzheimer disease (AD) cognitive impairment and patholog...
Apoptosis, or programmed cell death, is a cellular pathway involved in normal cell turnover, develop...
Apoptosis, or programmed cell death, is a cellular pathway involved in normal cell turnover, develop...
Apoptosis or programmed cell death is a cellular pathway involved in normal cell turnover, developm...
Apoptosis or programmed cell death is a cellular pathway involved in normal cell turnover, developm...
AbstractCaspase-6 (Casp6) is a short pro-domain caspase that is activated early in Alzheimer disease...
Caspase-6 is activated early in Alzheimer disease (AD) and localize to the pathologic...
Caspase-6 (Casp-6) is activated early in Alzheimer disease and involved in axonal degeneration, howe...
Active Caspase 6 associates with the neuropathological hallmarks of sporadic Alzheime...
Caspases, a family of cysteine proteases, are major mediators of apoptosis and inflammation. Caspase...
Caspase-6 (Casp6) is activated early in Alzheimer disease and involved in axonal degeneration, but t...
Caspases are a major contributor to the apoptotic pathway. We intended to investigate the role of ca...
The accumulation of amyloid beta (A beta) peptide (Amyloid cascade hypothesis), an APP protein cleav...
The accumulation of amyloid beta (A beta) peptide (Amyloid cascade hypothesis), an APP protein cleav...
The accumulation of amyloid beta (Aβ) peptide (Amyloid cascade hypothesis), an APP protein cleavage ...
Abstract Caspase-6 (Casp6) is implicated in Alzheimer disease (AD) cognitive impairment and patholog...
Apoptosis, or programmed cell death, is a cellular pathway involved in normal cell turnover, develop...
Apoptosis, or programmed cell death, is a cellular pathway involved in normal cell turnover, develop...
Apoptosis or programmed cell death is a cellular pathway involved in normal cell turnover, developm...
Apoptosis or programmed cell death is a cellular pathway involved in normal cell turnover, developm...
AbstractCaspase-6 (Casp6) is a short pro-domain caspase that is activated early in Alzheimer disease...
Caspase-6 is activated early in Alzheimer disease (AD) and localize to the pathologic...
Caspase-6 (Casp-6) is activated early in Alzheimer disease and involved in axonal degeneration, howe...
Active Caspase 6 associates with the neuropathological hallmarks of sporadic Alzheime...
Caspases, a family of cysteine proteases, are major mediators of apoptosis and inflammation. Caspase...
Caspase-6 (Casp6) is activated early in Alzheimer disease and involved in axonal degeneration, but t...
Caspases are a major contributor to the apoptotic pathway. We intended to investigate the role of ca...
The accumulation of amyloid beta (A beta) peptide (Amyloid cascade hypothesis), an APP protein cleav...
The accumulation of amyloid beta (A beta) peptide (Amyloid cascade hypothesis), an APP protein cleav...
The accumulation of amyloid beta (Aβ) peptide (Amyloid cascade hypothesis), an APP protein cleavage ...