β2 integrins are expressed on all leukocytes. Precise regulation of the β2 integrin is critical for leukocyte adhesion and trafficking. In neutrophils, β2 integrins participate in slow rolling. When activated by inside–out signaling, fully activated β2 integrins mediate rapid leukocyte arrest and adhesion. The two activation pathways, starting with selectin ligand engagement and chemokine receptor ligation, respectively, converge on phosphoinositide 3-kinase, talin-1, kindlin-3 and Rap1. Here, we focus on recent structural insights into autoinhibited talin-1 and autoinhibited trimeric kindlin-3. When activated, both talin-1 and kindlin-3 can bind the β2 cytoplasmic tail at separate but adjacent sites. We discuss possible pathways for talin-...
Integrins mediate cell-cell and cell-extracellular matrix attachments. Integrins are signaling recep...
SummaryIncreased ligand binding to cellular integrins (“activation”) plays important roles in proces...
AbstractThe integrin family of heterodimeric cell adhesion molecules exists in both low- and high-af...
β2 integrins are expressed on all leukocytes. Precise regulation of the β2 integrin is critical for ...
Integrins are heterodimeric cell adhesion molecules that are involved in many biological processes. ...
<div><p>Talins and kindlins bind to the integrin β3 cytoplasmic tail and both are required for effec...
Macrophage 1 (Mac1) integrin is a leukocyte-restricted adhesion molecule highly expressed on phagocy...
Leukocyte-endothelial adhesion and firm adhesion are chief steps in leukocyte recruitment cascade an...
Increased ligand binding to cellular integrins ("activation") plays important roles in processes suc...
Integrin αIIbβ3 is a predominant type of integrin abundantly expressed on the surface of platelets a...
Integrin-mediated cell adhesions are highly regulated structures forming between the cell and the ex...
Integrins mediate cell-cell and cell-extracellular matrix attachments. Integrins are signaling recep...
SummaryBackgroundIntegrins are heterodimeric αβ transmembrane receptors that play key roles in cellu...
Kindlin-3, a member of the FERM family proteins, functions as an adaptor between cell membrane and c...
Fundamental to cell adhesion and migration, integrins are large heterodimeric membrane proteins that...
Integrins mediate cell-cell and cell-extracellular matrix attachments. Integrins are signaling recep...
SummaryIncreased ligand binding to cellular integrins (“activation”) plays important roles in proces...
AbstractThe integrin family of heterodimeric cell adhesion molecules exists in both low- and high-af...
β2 integrins are expressed on all leukocytes. Precise regulation of the β2 integrin is critical for ...
Integrins are heterodimeric cell adhesion molecules that are involved in many biological processes. ...
<div><p>Talins and kindlins bind to the integrin β3 cytoplasmic tail and both are required for effec...
Macrophage 1 (Mac1) integrin is a leukocyte-restricted adhesion molecule highly expressed on phagocy...
Leukocyte-endothelial adhesion and firm adhesion are chief steps in leukocyte recruitment cascade an...
Increased ligand binding to cellular integrins ("activation") plays important roles in processes suc...
Integrin αIIbβ3 is a predominant type of integrin abundantly expressed on the surface of platelets a...
Integrin-mediated cell adhesions are highly regulated structures forming between the cell and the ex...
Integrins mediate cell-cell and cell-extracellular matrix attachments. Integrins are signaling recep...
SummaryBackgroundIntegrins are heterodimeric αβ transmembrane receptors that play key roles in cellu...
Kindlin-3, a member of the FERM family proteins, functions as an adaptor between cell membrane and c...
Fundamental to cell adhesion and migration, integrins are large heterodimeric membrane proteins that...
Integrins mediate cell-cell and cell-extracellular matrix attachments. Integrins are signaling recep...
SummaryIncreased ligand binding to cellular integrins (“activation”) plays important roles in proces...
AbstractThe integrin family of heterodimeric cell adhesion molecules exists in both low- and high-af...