Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino acids from their hosts. We previously identified a large family of apicomplexan-specific plasma membrane-localized amino acid transporters, the ApiATs, and showed that the Toxoplasma gondii transporter TgApiAT1 functions in the selective uptake of arginine. TgApiAT1 is essential for parasite virulence, but dispensable for parasite growth in medium containing high concentrations of arginine, indicating the presence of at least one other arginine transporter. Here we identify TgApiAT6-1 as the second arginine transporter. Using a combination of parasite assays and heterologous characterisation of TgApiAT6-1 in Xenopus laevis oocytes, we demons...
Toxoplasma gondii is a prevalent protozoan parasite that can infect any nucleated cell but cannot re...
Trypanosomatids' amino acid permeases are key proteins in parasite metabolism since they participate...
The apicoplast is a four-membrane plastid found in the apicomplexans, which harbors biosynthesis and...
Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino...
Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino...
Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino...
Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino...
Apicomplexans are obligate intracellular parasites that scavenge essential nutrients from their host...
Apicomplexan parasites are auxotrophic for a range of amino acids which must be salvaged from their ...
Apicomplexan parasites are auxotrophic for a range of amino acids which must be salvaged from their ...
Apicomplexan parasites are auxotrophic for a range of amino acids which must be salvaged from their ...
Intracellular parasites, such as the apicomplexan Toxoplasma gondii, are adept at scavenging nutrien...
To establish infection and disseminate within its host, the obligate intracellular parasite, Toxopl...
The Apicomplexan phylum is a large group of unicellular eukaryotic parasites. These parasites cause ...
Apicomplexan parasites are responsible for devastating diseases, including malaria, toxoplasmosis, a...
Toxoplasma gondii is a prevalent protozoan parasite that can infect any nucleated cell but cannot re...
Trypanosomatids' amino acid permeases are key proteins in parasite metabolism since they participate...
The apicoplast is a four-membrane plastid found in the apicomplexans, which harbors biosynthesis and...
Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino...
Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino...
Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino...
Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino...
Apicomplexans are obligate intracellular parasites that scavenge essential nutrients from their host...
Apicomplexan parasites are auxotrophic for a range of amino acids which must be salvaged from their ...
Apicomplexan parasites are auxotrophic for a range of amino acids which must be salvaged from their ...
Apicomplexan parasites are auxotrophic for a range of amino acids which must be salvaged from their ...
Intracellular parasites, such as the apicomplexan Toxoplasma gondii, are adept at scavenging nutrien...
To establish infection and disseminate within its host, the obligate intracellular parasite, Toxopl...
The Apicomplexan phylum is a large group of unicellular eukaryotic parasites. These parasites cause ...
Apicomplexan parasites are responsible for devastating diseases, including malaria, toxoplasmosis, a...
Toxoplasma gondii is a prevalent protozoan parasite that can infect any nucleated cell but cannot re...
Trypanosomatids' amino acid permeases are key proteins in parasite metabolism since they participate...
The apicoplast is a four-membrane plastid found in the apicomplexans, which harbors biosynthesis and...