Merkel cell polyomavirus (MCPyV) is the only human polyomavirus currently known to cause human cancer. MCPyV is believed to be an etiological factor in at least 80% of cases of the rare but aggressive skin malignancy Merkel cell carcinoma (MCC). In these MCPyV+ MCC tumors, clonal integration of the viral genome results in the continued expression of two viral proteins: the viral small T antigen (ST) and a truncated form of the viral large T antigen. The oncogenic potential of MCPyV and the functional properties of the viral T antigens that contribute to neoplasia are becoming increasingly well-characterized with the recent development of model systems that recapitulate the biology of MCPyV+ MCC. In this review, we summarize our understandin...
Merkel Cell Polyomavirus (MCPyV) genomes are clonally integrated in tumor tissues of approximately 8...
Merkel cell carcinoma (MCC) is a highly aggressive human cancer and its incidence is increasing worl...
Merkel cell carcinoma (MCC) is an increasingly common neuroendocrine cancer of the skin. MCC is an a...
AbstractA marked escalation in the rate of discovery of new types of human polyomavirus has occurred...
The Merkel cell polyomavirus (MCPyV), discovered in 2008, drives the development of most Merkel cell...
A fifth of worldwide cancer cases have an infectious origin, with viral infection being the foremost...
Merkel cell polyomavirus (MCV) is the etiological agent of Merkel cell carcinoma (MCC), a rare and h...
Merkel cell polyomavirus (MCV) is the etiological agent of Merkel cell carcinoma (MCC), a rare and h...
The work described in this dissertation was initiated in 2008, shortly after the discovery of Merkel...
Merkel cell polyomavirus (MCV) is the causative agent for the majority of Merkel cell carcinoma (MCC...
The work described in this dissertation was initiated in 2008, shortly after the discovery of Merkel...
Merkel cell polyomavirus (MCV) is one of the newer members of the polyomavirus family, recently disc...
Merkel cell polyomavirus (MCV) is one of the newer members of the polyomavirus family, recently disc...
Merkel cell polyomavirus (MCV) is a recently discovered human virus closely related to African green...
International audienceThe Merkel cell polyomavirus (MCPyV), identified in humans in 2008, is associa...
Merkel Cell Polyomavirus (MCPyV) genomes are clonally integrated in tumor tissues of approximately 8...
Merkel cell carcinoma (MCC) is a highly aggressive human cancer and its incidence is increasing worl...
Merkel cell carcinoma (MCC) is an increasingly common neuroendocrine cancer of the skin. MCC is an a...
AbstractA marked escalation in the rate of discovery of new types of human polyomavirus has occurred...
The Merkel cell polyomavirus (MCPyV), discovered in 2008, drives the development of most Merkel cell...
A fifth of worldwide cancer cases have an infectious origin, with viral infection being the foremost...
Merkel cell polyomavirus (MCV) is the etiological agent of Merkel cell carcinoma (MCC), a rare and h...
Merkel cell polyomavirus (MCV) is the etiological agent of Merkel cell carcinoma (MCC), a rare and h...
The work described in this dissertation was initiated in 2008, shortly after the discovery of Merkel...
Merkel cell polyomavirus (MCV) is the causative agent for the majority of Merkel cell carcinoma (MCC...
The work described in this dissertation was initiated in 2008, shortly after the discovery of Merkel...
Merkel cell polyomavirus (MCV) is one of the newer members of the polyomavirus family, recently disc...
Merkel cell polyomavirus (MCV) is one of the newer members of the polyomavirus family, recently disc...
Merkel cell polyomavirus (MCV) is a recently discovered human virus closely related to African green...
International audienceThe Merkel cell polyomavirus (MCPyV), identified in humans in 2008, is associa...
Merkel Cell Polyomavirus (MCPyV) genomes are clonally integrated in tumor tissues of approximately 8...
Merkel cell carcinoma (MCC) is a highly aggressive human cancer and its incidence is increasing worl...
Merkel cell carcinoma (MCC) is an increasingly common neuroendocrine cancer of the skin. MCC is an a...